2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite Fatty Acid Synthase (FASN)
  4. Coenzyme A sodium

Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

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CAS No. : 55672-92-9

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Based on 2 publication(s) in Google Scholar

Other Forms of Coenzyme A sodium:

Coenzyme A sodium Related Antibodies

Top Publications Citing Use of Products
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Flow Cytometry

    Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.

    Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.

    Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    Flow cytometry and quantification of IL-22 expression in CD8αβ+ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).

    Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.

    Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8.  [Abstract]

    phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.

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    Description

    Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Coenzyme A sodium Related Antibodies
    Molecular Weight

    833.48

    Formula

    C21H33N7Na3O16P3S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (59.99 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1998 mL 5.9989 mL 11.9979 mL
    5 mM 0.2400 mL 1.1998 mL 2.3996 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.46%

    SDS (393 KB)

    COA (247 KB) HNMR (306 KB) CNMR (259 KB) RP-HPLC (205 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.1998 mL 5.9989 mL 11.9979 mL 29.9947 mL
    5 mM 0.2400 mL 1.1998 mL 2.3996 mL 5.9989 mL
    10 mM 0.1200 mL 0.5999 mL 1.1998 mL 2.9995 mL
    15 mM 0.0800 mL 0.3999 mL 0.7999 mL 1.9996 mL
    20 mM 0.0600 mL 0.2999 mL 0.5999 mL 1.4997 mL
    25 mM 0.0480 mL 0.2400 mL 0.4799 mL 1.1998 mL
    30 mM 0.0400 mL 0.2000 mL 0.3999 mL 0.9998 mL
    40 mM 0.0300 mL 0.1500 mL 0.2999 mL 0.7499 mL
    50 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.5999 mL
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    Coenzyme A sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coenzyme A55672-92-9Endogenous MetaboliteFatty Acid Synthase (FASN)ubiquitous essential cofactoracyl group carriercitric acid cyclefatty acid metabolismmetabolismInhibitorinhibitorinhibit

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