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Cat. No.: HY-128851B

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Coenzyme A sodium

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

For research use only. We do not sell to patients.

Purity: 99.46%
CAS No.: 55672-92-9
Formula: C₂₁H₃₃N₇Na₃O₁₆P₃S
Molecular Weight:833.48

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Coenzyme A sodium Chemical Structure

CAS No.: 55672-92-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 55672-92-9
Appearance Solid
Molecular Weight 833.48
Formula C₂₁H₃₃N₇Na₃O₁₆P₃S
Color White to off-white
SMILES

CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (3)

All WBIHCFlow Cytometry

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Nature

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22. [Abstract]

2025 Nov;647(8090):706-715. PMID: 41034585

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Flow cytometry and quantification of IL-22 expression in CD8αβ⁺ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.
J Adv Res

c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis. [Abstract]

2025 Dec 8:S2090-1232(25)00996-8. PMID: 41371401

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]

phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.
Med Gas Res

Glycolysis-dependent reactive oxygen species mediate desmopressin acetate-induced rescue of platelet dysfunction caused by antiplatelet therapy. [Abstract]

2026 Mar 26. PMID: 41888039

Solvent & Solubility

In Vitro:

H2O : 50 mg/mL (59.99 mM; Need ultrasonic and warming)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1998 mL

5.9989 mL

11.9979 mL

5 mM

0.2400 mL

1.1998 mL

2.3996 mL

10 mM

0.1200 mL

0.5999 mL

1.1998 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-5. [Content Brief]

[2]. Tsuchiya Y, et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells. Biochem J. 2018 Jun 6;475(11):1909-1937. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	1.1998 mL	5.9989 mL	11.9979 mL	29.9947 mL
	5 mM	0.2400 mL	1.1998 mL	2.3996 mL	5.9989 mL
	10 mM	0.1200 mL	0.5999 mL	1.1998 mL	2.9995 mL
	15 mM	0.0800 mL	0.3999 mL	0.7999 mL	1.9996 mL
	20 mM	0.0600 mL	0.2999 mL	0.5999 mL	1.4997 mL
	25 mM	0.0480 mL	0.2400 mL	0.4799 mL	1.1998 mL
	30 mM	0.0400 mL	0.2000 mL	0.3999 mL	0.9998 mL
	40 mM	0.0300 mL	0.1500 mL	0.2999 mL	0.7499 mL
	50 mM	0.0240 mL	0.1200 mL	0.2400 mL	0.5999 mL

Keywords

Coenzyme A sodium

3 Cited Publications

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Customer Validation
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.
1/16

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Customer Validation
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.
1/16

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Customer Validation
Flow cytometry and quantification of IL-22 expression in CD8αβ⁺ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).
1/16

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Customer Validation
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.
1/16

Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]

Customer Validation
phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.

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Coenzyme A sodium

Publications Citing Use of MedChemExpress (MCE) Coenzyme A sodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Coenzyme A sodium Related Classifications

HY-128851B Related Classifications