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Coenzyme A 

Cat. No.: HY-128851 Purity: >97.0%
Handling Instructions

Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.

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Coenzyme A Chemical Structure

Coenzyme A Chemical Structure

CAS No. : 85-61-0

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10 mM * 1 mL in DMSO USD 51 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1].

Molecular Weight

767.53

Formula

C₂₁H₃₆N₇O₁₆P₃S

CAS No.

85-61-0

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(OCC(C)([[email protected]@H](O)C(NCCC(NCCS)=O)=O)C)(O)=O)(O)=O)[[email protected]]1OP(O)(O)=O)N2C3=NC=NC(N)=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: >97.0%

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Keywords:

Coenzyme AOthersInhibitorinhibitorinhibit

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