Coenzyme A trilithium

Name: Coenzyme A trilithium
Brand: MedChemExpress
SKU: HY-128851A
Rating: 5.0 (2 reviews)

Cat. No.: HY-128851A Purity: 99%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

For research use only. We do not sell to patients.

CAS No. : 18439-24-2

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Coenzyme A trilithium:

Coenzyme A In-stock
Coenzyme A sodium In-stock

2 Publications Citing Use of MCE Coenzyme A trilithium

IHC

Flow Cytometry

: Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]; CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.

: Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]; CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.

: Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]; Flow cytometry and quantification of IL-22 expression in CD8αβ⁺ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).

: Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]; CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.

: Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]; phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C₂₁H₃₃Li₃N₇O₁₆P₃S

CAS No.

18439-24-2

Appearance

Solid

Color

White to off-white

SMILES

CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O[Li])=O)(O[Li])=O)(O[Li])=O

Molecular Weight

785.33

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (159.17 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2734 mL	6.3668 mL	12.7335 mL
5 mM	0.2547 mL	1.2734 mL	2.5467 mL
10 mM	0.1273 mL	0.6367 mL	1.2734 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99%

Select Batch:

Data Sheet (272 KB) SDS (394 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-53. [Content Brief]

[2]. Tsuchiya Y, et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells. Biochem J. 2018 Jun 6;475(11):1909-1937. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2734 mL	6.3668 mL	12.7335 mL	31.8338 mL
	5 mM	0.2547 mL	1.2734 mL	2.5467 mL	6.3668 mL
	10 mM	0.1273 mL	0.6367 mL	1.2734 mL	3.1834 mL
	15 mM	0.0849 mL	0.4245 mL	0.8489 mL	2.1223 mL
	20 mM	0.0637 mL	0.3183 mL	0.6367 mL	1.5917 mL
	25 mM	0.0509 mL	0.2547 mL	0.5093 mL	1.2734 mL
	30 mM	0.0424 mL	0.2122 mL	0.4245 mL	1.0611 mL
	40 mM	0.0318 mL	0.1592 mL	0.3183 mL	0.7958 mL
	50 mM	0.0255 mL	0.1273 mL	0.2547 mL	0.6367 mL
	60 mM	0.0212 mL	0.1061 mL	0.2122 mL	0.5306 mL
	80 mM	0.0159 mL	0.0796 mL	0.1592 mL	0.3979 mL
	100 mM	0.0127 mL	0.0637 mL	0.1273 mL	0.3183 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.