Coenzyme A trilithium
Based on 4 publication(s) in Google Scholar
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 18439-24-2
- Formula: C21H33Li3N7O16P3S
- Molecular Weight:785.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Coenzyme A trilithium
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Customer Validation & Images
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WB
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IHC
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Flow Cytometry
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IHC
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18439-24-2
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Appearance Solid
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Molecular Weight 785.33
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Formula C21H33Li3N7O16P3S
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Color White to off-white
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SMILES
CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O[Li])=O)(O[Li])=O)(O[Li])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Nov;647(8090):706-715. PMID: 41034585
Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.
Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.
Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]
Flow cytometry and quantification of IL-22 expression in CD8αβ+ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).
Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]
CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.
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J Adv Res
A "DUBTAC" targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes. [Abstract]2026 Apr 13:S2090-1232(26)00338-3. PMID: 41980623 -
J Adv Res
c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis. [Abstract]2025 Dec 8:S2090-1232(25)00996-8. PMID: 41371401
Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.
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Med Gas Res
Glycolysis-dependent reactive oxygen species mediate desmopressin acetate-induced rescue of platelet dysfunction caused by antiplatelet therapy. [Abstract]2026 Mar 26. PMID: 41888039
Solvent & Solubility
H2O : 125 mg/mL (159.17 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.2734 mL | 6.3668 mL | 12.7335 mL | 31.8338 mL |
| 5 mM | 0.2547 mL | 1.2734 mL | 2.5467 mL | 6.3668 mL | |
| 10 mM | 0.1273 mL | 0.6367 mL | 1.2734 mL | 3.1834 mL | |
| 15 mM | 0.0849 mL | 0.4245 mL | 0.8489 mL | 2.1223 mL | |
| 20 mM | 0.0637 mL | 0.3183 mL | 0.6367 mL | 1.5917 mL | |
| 25 mM | 0.0509 mL | 0.2547 mL | 0.5093 mL | 1.2734 mL | |
| 30 mM | 0.0424 mL | 0.2122 mL | 0.4245 mL | 1.0611 mL | |
| 40 mM | 0.0318 mL | 0.1592 mL | 0.3183 mL | 0.7958 mL | |
| 50 mM | 0.0255 mL | 0.1273 mL | 0.2547 mL | 0.6367 mL | |
| 60 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5306 mL | |
| 80 mM | 0.0159 mL | 0.0796 mL | 0.1592 mL | 0.3979 mL | |
| 100 mM | 0.0127 mL | 0.0637 mL | 0.1273 mL | 0.3183 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Coenzyme A trilithium Related Classifications
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