1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMSpep-57

BMSpep-57 

Cat. No.: HY-P3143
Handling Instructions

BMSpep-57 is a potent and competite macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs. BMSpep-57 exhibits favorable drug-like properties and strong immunological activity in vitro.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BMSpep-57 Chemical Structure

BMSpep-57 Chemical Structure

CAS No. : 1629655-80-6

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Description

BMSpep-57 is a potent and competite macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs. BMSpep-57 exhibits favorable drug-like properties and strong immunological activity in vitro[1].

In Vitro

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in  SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1868.17

Formula

C₈₉H₁₂₆N₂₄O₁₉S

CAS No.

1629655-80-6

Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)

Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BMSpep-57BMSpep57BMSpep 57PD-1/PD-L1PD-1/Programmed death-ligand 1IL-2 productionPBMCdrug-likeimmunologicalInhibitorinhibitorinhibit

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