1629655-80-6
Chemical Structure
BMSpep-57
- CAS No.: 1629655-80-6
- Formula:C89H126N24O19S
- Molecular Weight:1868.17
InChIKey: CQENCADPYMYPOU-BYUPMXPTSA-N
SMILES: O=C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2)=O)CO)=O)CC3=CNC4=CC=CC=C34)=O)CO)=O)CC(C)C)=O)CC5=CN=CN5)=O)=O)CC(N)=O)=O)C)C)=O)CC6=CC=CC=C6)=O)C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CCCC)C)=O)CCCC)C)[C@@H]2CC7=CNC8=CC=CC=C78
Biological Activity: BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMSpep-57 | 99.87% | BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs. | ||||||||||||||||||||
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Keywords
