Antitumor agent-127 

Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines^[1].

Antitumor agent-127 (compound 1) dose not induce apoptosis in Mia PaCa-2 cells, a model pancreatic tumor cell line with a relatively low level of cell surface expression of ROR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1670.92

C₈₆H₁₀₇N₁₅O₁₈S

O=C(N[C@H](C(NCC(N)=O)=O)CSCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(NCC(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H]5CC6=CC=C(O)C=C6)=O)=O)=O)CO)=O)=O)C(C)C)=O)=O)=O)CC7=CC=CC=C7)=O)[C@H](CC(C)C)NC([C@H](CC8=CC=CC=C8)N(C)C5=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qiao JX, et al. Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1). Bioorg Med Chem Lett. 2023 Dec 13;98:129589.  [Content Brief]