Cyclic L27-11
Based on 1 Customer Validation
Cyclic L27-11 is a peptidomimetic compound targeting the bacterial outer membrane protein LptD. Cyclic L27-11 exhibits nanomolar antibacterial activity against Pseudomonas aeruginosa. Cyclic L27-11 binds to LptD and inhibits the translocation of lipopolysaccharides to the cell surface. Cyclic L27-11 can be used in studies related to Pseudomonas aeruginosa infection.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 1221423-80-8
- Formula: C87H141N27O15
- Molecular Weight:1805.22
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Cyclic L27-11 potently inhibits growth of Pseudomonas aeruginosa ATCC 27853 with an MIC of 0.01 μg/mL, with Trp2 and Trp8 side chains being critical for maintaining this antimicrobial activity[1].
Cyclic L27-11 populates nascent β-hairpin-like structures in aqueous solution, with residues near the DPro-LPro template most constrained and increasing flexibility toward the Arg6-Arg7 loop tip[1].
Cyclic L27-11 exhibits a far-UV CD spectrum in aqueous solution consistent with β-hairpin secondary structure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1221423-80-8
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Appearance Solid
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Molecular Weight 1805.22
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Formula C87H141N27O15
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Color White to light yellow
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Sequence
cyclo(Thr-Trp-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Lys-Ala-Lys-{d-Pro}-Pro)
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Sequence Shortening
cyclo(TWLKKRRWKKAK-{d-Pro}-P)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (13.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (303 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5539 mL | 2.7697 mL | 5.5395 mL | 13.8487 mL |
| 5 mM | 0.1108 mL | 0.5539 mL | 1.1079 mL | 2.7697 mL | |
| 10 mM | 0.0554 mL | 0.2770 mL | 0.5539 mL | 1.3849 mL |
Cyclic L27-11 Related Classifications
HY-P10548 Related Classifications
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