Ub4ix
Based on 1 Customer Validation
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 2396736-46-0
- Formula: C84H106N18O23S
- Molecular Weight:1767.91
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 2396736-46-0
-
Appearance Solid
-
Molecular Weight 1767.91
-
Formula C84H106N18O23S
-
Color White to off-white
-
Sequence
cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether
-
Sequence Shortening
cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (56.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (283 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11(7):644-652. [Content Brief]
[2]. Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56(14):1953-1965. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5656 mL | 2.8282 mL | 5.6564 mL | 14.1410 mL |
| 5 mM | 0.1131 mL | 0.5656 mL | 1.1313 mL | 2.8282 mL | |
| 10 mM | 0.0566 mL | 0.2828 mL | 0.5656 mL | 1.4141 mL | |
| 15 mM | 0.0377 mL | 0.1885 mL | 0.3771 mL | 0.9427 mL | |
| 20 mM | 0.0283 mL | 0.1414 mL | 0.2828 mL | 0.7070 mL | |
| 25 mM | 0.0226 mL | 0.1131 mL | 0.2263 mL | 0.5656 mL | |
| 30 mM | 0.0189 mL | 0.0943 mL | 0.1885 mL | 0.4714 mL | |
| 40 mM | 0.0141 mL | 0.0707 mL | 0.1414 mL | 0.3535 mL | |
| 50 mM | 0.0113 mL | 0.0566 mL | 0.1131 mL | 0.2828 mL |
Powered by Bioz