2396736-46-0
Chemical Structure
Ub4ix
- CAS No.: 2396736-46-0
- Formula:C84H106N18O23S
- Molecular Weight:1767.91
InChIKey: YJXMJZDKFPZVBL-BSZGTXCISA-N
SMILES: O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC(CSC[C@H](NC([C@](NC1=O)([H])[C@@H](C)CC)=O)C(NCC(N)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)CC(C)C)=O)CC4=CC=C(C=C4)O)=O)CC(C)C)=O)CC(O)=O)=O)CC(O)=O)=O)CO)=O)=O)CC(O)=O)=O)CC5=CNC6=CC=CC=C56)N[C@H]1CC7=CNC8=CC=CC=C78
Biological Activity:
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ub4ix | 99.32% | Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM. |
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References
- [1]. Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11(7):644-652. [Content Brief]
- [2]. Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56(14):1953-1965. [Content Brief]
