G7-18NATE
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 936728-13-1
- Formula: C67H80N14O19S
- Molecular Weight:1417.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
G7-18NATE (10 μM, 24 h) inhibits cell migration in MDA-MB-468 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Somatic Cell Culture
- Organoid Passaging and Mechanical Expansion Protocols
- ECM-Embedded Organoid (Matrigel/Dome) Culture
- Hanging Drop Spheroid Culture
- Organotypic 3D Invasion Assay
- Cell invasion
- Matrigel/ECM Transwell Invasion Assay
- MTT Cell Proliferation Assay
- 3D Collagen/Hydrogel Matrix Invasion Assay
- Spheroid/Tumor Organoid Invasion Assay
- Ex Vivo Tissue Slice/Explant Invasion Assay
- Patient-Derived Organoid Invasion Assay
- BrdU Incorporation Assay
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- 3D Tumor Spheroid Invasion Assay
- Cell Viability Determination by MTT Colorimetric Assay
- Matrigel Transwell/Boyden Chamber Invasion Assay
- Invadopodia/Fluorescent Gelatin Degradation Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
Chemical Information
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CAS No. 936728-13-1
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Molecular Weight 1417.50
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Formula C67H80N14O19S
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Sequence
cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-)
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Sequence Shortening
cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [Content Brief]
[2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G7-18NATE Related Classifications
HY-P10224 Related Classifications
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