WL12
Based on 1 Customer Validation
WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 1886057-64-2
- Formula: C91H128N22O20S
- Molecular Weight:1882.19
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Peptide |
WL12 can be conjugated with NOTA and labeled with 64Cu for micro-PET/CT imaging. 64Cu-NOTA-WL12 is a peptide with high stability and high affinity that specifically targets PD-L1, and it can noninvasively evaluate the expression level of PD-L1 in tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1886057-64-2
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Appearance Solid
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Molecular Weight 1882.19
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Formula C91H128N22O20S
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Color White to off-white
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Sequence
Cyclo(Ac-Y-{Ala(Me)}-NPHL-{Hyp}-Trp-Ser-{Trp(Me)}-{Nle(Me)}-{Nle(Me)}-{Orn}-Cys)Gly-NH2 (Thioether bridge: Cys14-Ac-Tyr)
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Sequence Shortening
Cyclo(Ac-Y-{Ala(Me)}-NPHL-{Hyp}-WS-{Trp(Me)}-{Nle(Me)}-{Nle(Me)}-{Orn}-C)G-NH2 (Thioether bridge: Cys14-Ac-Tyr)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : 50 mg/mL (26.56 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.5313 mL | 2.6565 mL | 5.3130 mL | 13.2824 mL |
| 5 mM | 0.1063 mL | 0.5313 mL | 1.0626 mL | 2.6565 mL | |
| 10 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.3282 mL | |
| 15 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.8855 mL | |
| 20 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.6641 mL | |
| 25 mM | 0.0213 mL | 0.1063 mL | 0.2125 mL | 0.5313 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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