1. Metabolic Enzyme/Protease
  2. LXR
  3. Yamogenin

Yamogenin (Synonyms: Neodiosgenin)

Cat. No.: HY-N2078 Purity: 99.20%
Handling Instructions

Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.

For research use only. We do not sell to patients.

Yamogenin Chemical Structure

Yamogenin Chemical Structure

CAS No. : 512-06-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 820 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].

IC50 & Target

IC50: TG accumulation; liver X receptor (LXR)[1]

Molecular Weight

414.62

Formula

C₂₇H₄₂O₃

CAS No.

512-06-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 10 mg/mL (24.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4118 mL 12.0592 mL 24.1185 mL
5 mM 0.4824 mL 2.4118 mL 4.8237 mL
10 mM 0.2412 mL 1.2059 mL 2.4118 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 1 mg/mL (2.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

YamogeninNeodiosgeninLXRLiver X receptorDiastereomerTGtriacylglyceridefatty acid synthesisInhibitorinhibitorinhibit

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Yamogenin
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HY-N2078
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