1. Metabolic Enzyme/Protease
  2. Fatty Acid Synthase (FASN)
  3. BI 99179

BI 99179 

Cat. No.: HY-16100 Purity: 99.78%
Handling Instructions

BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats.

For research use only. We do not sell to patients.

BI 99179 Chemical Structure

BI 99179 Chemical Structure

CAS No. : 1291779-76-4

Size Price Stock Quantity
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1][2].

IC50 & Target

IC50: 79 nM (FASN)[1]

In Vitro

BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].
BI 99179 (BI-99179; 1, 2, and 4 µM) shows antiproliferative efficacy in human glioma GAMG cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human glioma GAMG cells
Concentration: 1, 2, 4 µM
Incubation Time: 96 to 120 hours
Result: The optimal palmitate concentration for GAMG cell line was 4 µM.
In Vivo

BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t1/2) of 3.0 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

391.46

Formula

C₂₃H₂₅N₃O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (319.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5545 mL 12.7727 mL 25.5454 mL
5 mM 0.5109 mL 2.5545 mL 5.1091 mL
10 mM 0.2555 mL 1.2773 mL 2.5545 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
BI 99179
Cat. No.:
HY-16100
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