1. Metabolic Enzyme/Protease
  2. Fatty Acid Synthase (FAS)
  3. BI99179

BI99179 

Cat. No.: HY-16100
Handling Instructions

BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats.

For research use only. We do not sell to patients.

BI99179 Chemical Structure

BI99179 Chemical Structure

CAS No. : 1291779-76-4

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Description

BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].

IC50 & Target

IC50: 79 nM (FAS)[1]

In Vitro

BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].

In Vivo

BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1].

Molecular Weight

391.46

Formula

C₂₃H₂₅N₃O₃

CAS No.

1291779-76-4

SMILES

O=C([[email protected]]1C[[email protected]@H](NC(CC)=O)CC1)N(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BI99179BI 99179BI-99179Fatty Acid Synthase (FAS)FattyacidsynthaseFASCNSexposureInhibitorinhibitorinhibit

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