1291779-76-4
Chemical Structure
BI 99179
- CAS No.: 1291779-76-4
- Formula:C23H25N3O3
- Molecular Weight:391.46
IUPAC Name: (1R,3S)-N-(4-(benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentane-1-carboxamide
InChIKey: YNFDIGJKJPNFFD-SJORKVTESA-N
SMILES: O=C([C@H]1C[C@@H](NC(CC)=O)CC1)N(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C
Biological Activity: BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1][2].
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BI 99179 | 99.38% | BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats. | ||||||||||||||||||||
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- [1]. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7. [Content Brief]
- [2]. Prosanta K Singha, et al. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells. Eur J Pharm Sci. 2020 Apr 7;149:105321. [Content Brief]
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