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  3. Glufosinate

Glufosinate 

Cat. No.: HY-W019870A
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Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity.

For research use only. We do not sell to patients.

Glufosinate Chemical Structure

Glufosinate Chemical Structure

CAS No. : 51276-47-2

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Description

Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].

In Vitro

Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].
Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].
Glufosinate impairs ependymal cell capability to synthetize cilia[2].

In Vivo

Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3].
The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].

Molecular Weight

181.13

Formula

C₅H₁₂NO₄P

CAS No.

51276-47-2

SMILES

CP(O)(CCC(N)C(O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GlufosinateOthersphosphinicacidanalogueplantCelsr2 neurotoxic adhesiondifferentiatedneuralstemcellInhibitorinhibitorinhibit

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