Glufosinate ammonium
Based on 1 publication(s) in Google Scholar
Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.
For research use only. We do not sell to patients.
- Purity: 99.29%
- CAS No.: 77182-82-2
- Formula: C5H15N2O4P
- Molecular Weight:198.16
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Glufosinate ammonium
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Biological Activity
Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].
Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].
Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ependymal cells
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Concentration:1, 3, 10, 100 μM
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Incubation Time:During 12DIV (NSCs-to-ependymal cells time point)
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Result:Significantly decreased Celsr2 gene expression at 100 μM.
The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 77182-82-2
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Appearance Solid
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Molecular Weight 198.16
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Formula C5H15N2O4P
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Color White to off-white
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SMILES
CP(O)(CCC(N)C(O)=O)=O.N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Microbiome
An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria. [Abstract]2024 Oct 15;12(1):202. PMID: 39407320
Solvent & Solubility
H2O : 250 mg/mL (1261.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (504.64 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945. [Content Brief]
[2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163. [Content Brief]
[3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0464 mL | 25.2321 mL | 50.4643 mL | 126.1607 mL |
| 5 mM | 1.0093 mL | 5.0464 mL | 10.0929 mL | 25.2321 mL | |
| 10 mM | 0.5046 mL | 2.5232 mL | 5.0464 mL | 12.6161 mL | |
| 15 mM | 0.3364 mL | 1.6821 mL | 3.3643 mL | 8.4107 mL | |
| 20 mM | 0.2523 mL | 1.2616 mL | 2.5232 mL | 6.3080 mL | |
| 25 mM | 0.2019 mL | 1.0093 mL | 2.0186 mL | 5.0464 mL | |
| 30 mM | 0.1682 mL | 0.8411 mL | 1.6821 mL | 4.2054 mL | |
| 40 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1540 mL | |
| 50 mM | 0.1009 mL | 0.5046 mL | 1.0093 mL | 2.5232 mL | |
| 60 mM | 0.0841 mL | 0.4205 mL | 0.8411 mL | 2.1027 mL | |
| 80 mM | 0.0631 mL | 0.3154 mL | 0.6308 mL | 1.5770 mL | |
| 100 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2616 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Glufosinate ammonium Related Classifications
HY-W019870 Related Classifications
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