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Glufosinate ammonium 

Cat. No.: HY-W019870 Purity: >98.0%
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Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.

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Glufosinate ammonium Chemical Structure

Glufosinate ammonium Chemical Structure

CAS No. : 77182-82-2

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Based on 1 publication(s) in Google Scholar

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Description

Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].

In Vitro

Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].
Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].
Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2].

RT-PCR[2]

Cell Line: Ependymal cells
Concentration: 1, 3, 10, 100 μM
Incubation Time: During 12DIV (NSCs-to-ependymal cells time point)
Result: Significantly decreased Celsr2 gene expression at 100 μM.
In Vivo

Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3].
The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].

Molecular Weight

198.16

Formula

C₅H₁₅N₂O₄P

CAS No.

77182-82-2

SMILES

CP(O)(CCC(N)C(O[NH4])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1261.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0464 mL 25.2321 mL 50.4643 mL
5 mM 1.0093 mL 5.0464 mL 10.0929 mL
10 mM 0.5046 mL 2.5232 mL 5.0464 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

GlufosinateOthersphosphinicacidanalogueplantCelsr2 neurotoxic adhesiondifferentiatedneuralstemcellInhibitorinhibitorinhibit

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Glufosinate ammonium
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HY-W019870
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