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  4. Glufosinate ammonium

Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.

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Glufosinate ammonium Chemical Structure

Glufosinate ammonium Chemical Structure

CAS No. : 77182-82-2

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Solid + Solvent
10 mM * 1 mL in Water
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Based on 1 publication(s) in Google Scholar

Other Forms of Glufosinate ammonium:

Glufosinate ammonium Related Antibodies

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Description

Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].

In Vitro

Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].
Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].
Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glufosinate ammonium Related Antibodies

RT-PCR[2]

Cell Line: Ependymal cells
Concentration: 1, 3, 10, 100 μM
Incubation Time: During 12DIV (NSCs-to-ependymal cells time point)
Result: Significantly decreased Celsr2 gene expression at 100 μM.
In Vivo

Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3].
The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

198.16

Formula

C5H15N2O4P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CP(O)(CCC(N)C(O)=O)=O.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1261.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0464 mL 25.2321 mL 50.4643 mL
5 mM 1.0093 mL 5.0464 mL 10.0929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (504.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (229 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0464 mL 25.2321 mL 50.4643 mL 126.1607 mL
5 mM 1.0093 mL 5.0464 mL 10.0929 mL 25.2321 mL
10 mM 0.5046 mL 2.5232 mL 5.0464 mL 12.6161 mL
15 mM 0.3364 mL 1.6821 mL 3.3643 mL 8.4107 mL
20 mM 0.2523 mL 1.2616 mL 2.5232 mL 6.3080 mL
25 mM 0.2019 mL 1.0093 mL 2.0186 mL 5.0464 mL
30 mM 0.1682 mL 0.8411 mL 1.6821 mL 4.2054 mL
40 mM 0.1262 mL 0.6308 mL 1.2616 mL 3.1540 mL
50 mM 0.1009 mL 0.5046 mL 1.0093 mL 2.5232 mL
60 mM 0.0841 mL 0.4205 mL 0.8411 mL 2.1027 mL
80 mM 0.0631 mL 0.3154 mL 0.6308 mL 1.5770 mL
100 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.2616 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glufosinate ammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glufosinate77182-82-2OthersphosphinicacidanalogueplantCelsr2 neurotoxic adhesiondifferentiatedneuralstemcellInhibitorinhibitorinhibit

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