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Glufosinate ammonium 

Cat. No.: HY-W019870 Purity: ≥98.0%
COA Handling Instructions

Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.

For research use only. We do not sell to patients.

Glufosinate ammonium Chemical Structure

Glufosinate ammonium Chemical Structure

CAS No. : 77182-82-2

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Based on 1 publication(s) in Google Scholar

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Description

Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].

In Vitro

Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].
Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].
Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: Ependymal cells
Concentration: 1, 3, 10, 100 μM
Incubation Time: During 12DIV (NSCs-to-ependymal cells time point)
Result: Significantly decreased Celsr2 gene expression at 100 μM.
In Vivo

Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3].
The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

198.16

Appearance

Solid

Formula

C5H15N2O4P
CAS No.
SMILES

CP(O)(CCC(N)C(O)=O)=O.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1261.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0464 mL 25.2321 mL 50.4643 mL
5 mM 1.0093 mL 5.0464 mL 10.0929 mL
10 mM 0.5046 mL 2.5232 mL 5.0464 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (504.64 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (236 KB) CNMR (278 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Glufosinate77182-82-2OthersphosphinicacidanalogueplantCelsr2 neurotoxic adhesiondifferentiatedneuralstemcellInhibitorinhibitorinhibit

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