Neurotoxic Agent

Neurotoxicity refers to the adverse effects of chemicals or toxins on the nervous system, leading to structural and functional impairments in neural cells, disruption of neurotransmitter activities, and resulting in cognitive, behavioral, and developmental deficits. It can arise from direct damage to neurons and axons or indirect mechanisms such as impaired blood supply and metabolism, often caused by environmental contaminants like persistent organic pollutants (POPs), including PCBs and dioxins. These exposures may cause temporary or permanent neurological dysfunction, with clinical manifestations ranging from subtle neurochemical changes to severe neurological disorders and developmental delays.

References:

[1]. Neurotoxicity. sciencedirect.

Neurotoxic Agent (2):

Targets:	nAChR (2) Cholinesterase (ChE) (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-182010

nAChR antagonist 3	3114746-65-2
nAChR antagonist 3 is a selective α7 nAChR antagonist with an IC₅₀ of 0.86 μM. nAChR antagonist 3 exerts a protective effect against paraoxon-induced toxicity. nAChR antagonist 3 can be used for the research of organophosphate poisoning.

HY-106901B

Asoxime dimesylate	144252-71-1
Asoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system.

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