56-55-3
![Benz[a]anthracene Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-w012278.gif "Benz[a]anthracene Chemical Structure")
Chemical Structure
Benz[a]anthracene
Synonym(s): Tetraphene
- CAS No.: 56-55-3
- Formula:C18H12
- Molecular Weight:228.29
IUPAC Name: tetraphene
InChIKey: DXBHBZVCASKNBY-UHFFFAOYSA-N
SMILES: C12=CC=CC=C1C3=CC4=CC=CC=C4C=C3C=C2
Biological Activity: Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Benz[a]anthracene | 99.90% | Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Benz[a]anthracene-d12 | 99.74% | Benz[a]anthracene-d12 (Tetraphene-d12) is the deuterated-labeled Benz[a]anthracene (HY-W012278). Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Lo Piparo E, et al. Virtual screening for aryl hydrocarbon receptor binding prediction. J Med Chem. 2006;49(19):5702-5709. [Content Brief]
- [2]. Zhao H, et al. Dissecting the long-term neurobehavioral impact of embryonic benz[a]anthracene exposure on zebrafish: Social dysfunction and molecular pathway activation. The Science of the total environment. 2024 Jun 20;930:172615.
- [3]. Schuler L, et al. Characterization of a ring-hydroxylating dioxygenase from phenanthrene-degrading Sphingomonas sp. strain LH128 able to oxidize benz[a]anthracene. Appl Microbiol Biotechnol. 2009 Jun;83(3):465-75.
