Asoxime dimesylate
Asoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system.
For research use only. We do not sell to patients.
- CAS No.: 144252-71-1
- Formula: C16H22N4O9S2
- Molecular Weight:478.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE |
Chemical Information
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CAS No. 144252-71-1
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Molecular Weight 478.50
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Formula C16H22N4O9S2
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SMILES
O=C(C1=CC=[N+](COC[N+]2=C(/C=N/O)C=CC=C2)C=C1)N.O=S([O-])(C)=O.O=S([O-])(C)=O
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Synonyms
HI-6 dimesylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6. [Content Brief]
[2]. Lundy PM, et al. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev. 2006;25(4):231-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asoxime dimesylate Related Classifications
HY-106901B Related Classifications
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