1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Asoxime dichloride

Asoxime dichloride (Synonyms: HI-6)

Cat. No.: HY-106901A
Handling Instructions

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system.

For research use only. We do not sell to patients.

Asoxime dichloride Chemical Structure

Asoxime dichloride Chemical Structure

CAS No. : 34433-31-3

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Description

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

IC50 & Target

IC50: acetylcholine receptors (AChRs)[1]

In Vivo

Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1].

Animal Model: Balb/c mice[1]
Dosage: 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg
Administration: Intramuscular injection into the rear limb
Result: Improved vaccination efficacy at the level of immunity regulation by the nervous system.
Molecular Weight

359.21

Formula

C₁₄H₁₆Cl₂N₄O₃

CAS No.

34433-31-3

SMILES

O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Asoxime dichlorideHI-6HI6HI 6nAChRNicotinic acetylcholine receptorsAChRnervousvaccinationantigenInhibitorinhibitorinhibit

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Asoxime dichloride
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