2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Asoxime dichloride

Asoxime dichloride  (Synonyms: HI-6)

Cat. No.: HY-106901A
Handling Instructions

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system.

For research use only. We do not sell to patients.

Asoxime dichloride Chemical Structure

Asoxime dichloride Chemical Structure

CAS No. : 34433-31-3

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Based on 1 publication(s) in Google Scholar

Asoxime dichloride Related Antibodies

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Description

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

IC50 & Target

IC50: acetylcholine receptors (AChRs)[1]
In Vivo

Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[1]
Dosage: 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg
Administration: Intramuscular injection into the rear limb
Result: Improved vaccination efficacy at the level of immunity regulation by the nervous system.
Molecular Weight

359.21

Formula

C14H16Cl2N4O3
CAS No.
SMILES

O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Asoxime dichloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Asoxime dichloride34433-31-3HI-6HI6HI 6nAChRNicotinic acetylcholine receptorsAChRnervousvaccinationantigenInhibitorinhibitorinhibit

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