144252-71-1
Chemical Structure
Asoxime dimesylate
Synonym(s): HI-6 dimesylate
- CAS No.: 144252-71-1
- Formula:C16H22N4O9S2
- Molecular Weight:478.50
IUPAC Name: mono((E)-1-(((4-carbamoylpyridin-1-ium-1-yl)methoxy)methyl)-2-((hydroxyimino)methyl)pyridin-1-ium) monomethanesulfonate
InChIKey: KSZUKDJWBYNHBO-UHFFFAOYSA-N
SMILES: O=C(C1=CC=[N+](COC[N+]2=C(/C=N/O)C=CC=C2)C=C1)N.O=S([O-])(C)=O.O=S([O-])(C)=O
Biological Activity: Asoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system[1][2].
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Asoxime dimesylate | Asoxime dimesylate (HI-6 dimesylate) is an orally active thiosemicarbazone-based antidote. Asoxime dimesylate is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dimesylate significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dimesylate is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dimesylate can serve as an effective immunomodulator, improving the immune effect of the nervous system. | |||||||||||||||||||||
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- [1]. Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6. [Content Brief]
- [2]. Lundy PM, et al. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev. 2006;25(4):231-43. [Content Brief]
Keywords
