1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Abeprazan hydrochloride

Abeprazan hydrochloride (Synonyms: DWP14012 hydrochloride)

Cat. No.: HY-109079A
Handling Instructions

Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.

For research use only. We do not sell to patients.

Abeprazan hydrochloride Chemical Structure

Abeprazan hydrochloride Chemical Structure

CAS No. : 1902954-87-3

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Description

Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].

In Vitro

The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].

In Vivo

Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].

Clinical Trial
Molecular Weight

446.87

Formula

C₁₉H₁₈ClF₃N₂O₃S

CAS No.

1902954-87-3

SMILES

CNCC1=CN(S(=O)(C2=CC=CC(F)=C2)=O)C(C3=CC=C(F)C=C3F)=C1OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AbeprazanDWP14012DWP 14012DWP-14012Proton PumppotassiumcompetitiveprotonpumpgastricacidsecretionInhibitorinhibitorinhibit

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Abeprazan hydrochloride
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HY-109079A
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