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Cat. No.: HY-118347

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Aspartame acesulfame

Name: Aspartame acesulfame
Brand: MedChemExpress
SKU: HY-118347
Price: 50.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).

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CAS No.: 106372-55-8
Formule: C₁₈H₂₃N₃O₉S
Masse moléculaire:457.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aspartame acesulfame Chemical Structure

CAS No.: 106372-55-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (3)
Pureté et documentation
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Description

In Vitro

Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aspartame (4000 mg/kg bw/day; p.o.) shows no adverse effect in acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 106372-55-8
Masse moléculaire 457.45
Formule C₁₈H₂₃N₃O₉S
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All Bio/Physico-chemical AssayCell Imaging/StainingCell Proliferation/Viability Assay

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Journal Impact Factor

Environ Pollut

Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1. [Abstract]

2024 Nov 15:361:124792. PMID: 39182820
Ecotoxicol Environ Saf

2026 Aug:321:120456. PMID: 42385372
Naunyn Schmiedebergs Arch Pharmacol

Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer. [Abstract]

2026 Jun 19. PMID: 42319418

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Venn diagram showing the overlap between CRC-related candidate genes and APM (Aspartame) candidate targets, resulting in 26 APM-CRC common candidate genes.

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Heatmap of the binding energies between APM and the five key target proteins.

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

EdU staining showed that, compared with the DMSO control group, the number of EdU-positive cells in HCT116 and SW480 cells was significantly increased after APM (Aspartame, 0.001-0.1 mM) treatment, exhibiting a dose-dependent increase.

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

CCK-8 assay of HCT116 and SW480 cells treated with APM (Aspartame) for 24, 48, and 72 h.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727. [Content Brief]

[2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Aspartame acesulfame

3 Cited Publications

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Activité biologique
- Description
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (3)
Pureté et documentation
Références

1/16
1/16

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Customer Validation
Venn diagram showing the overlap between CRC-related candidate genes and APM (Aspartame) candidate targets, resulting in 26 APM-CRC common candidate genes.
1/16

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Customer Validation
Heatmap of the binding energies between APM and the five key target proteins.
1/16

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Customer Validation
EdU staining showed that, compared with the DMSO control group, the number of EdU-positive cells in HCT116 and SW480 cells was significantly increased after APM (Aspartame, 0.001-0.1 mM) treatment, exhibiting a dose-dependent increase.
1/16

Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]

Customer Validation
CCK-8 assay of HCT116 and SW480 cells treated with APM (Aspartame) for 24, 48, and 72 h.

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Aspartame acesulfame

Publications Citing Use of MedChemExpress (MCE) Aspartame acesulfame