Aspartame acesulfame
Based on 2 publication(s) in Google Scholar
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).
For research use only. We do not sell to patients.
- CAS No.: 106372-55-8
- Formula: C18H23N3O9S
- Molecular Weight:457.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Aspartame acesulfame
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Biological Activity
Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 106372-55-8
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Molecular Weight 457.45
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Formula C18H23N3O9S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Environ Pollut
Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1. [Abstract]2024 Nov 15:361:124792. PMID: 39182820 -
Naunyn Schmiedebergs Arch Pharmacol
Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer. [Abstract]2026 Jun 19. PMID: 42319418
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
Venn diagram showing the overlap between CRC-related candidate genes and APM (Aspartame) candidate targets, resulting in 26 APM-CRC common candidate genes.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
Heatmap of the binding energies between APM and the five key target proteins.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
EdU staining showed that, compared with the DMSO control group, the number of EdU-positive cells in HCT116 and SW480 cells was significantly increased after APM (Aspartame, 0.001-0.1 mM) treatment, exhibiting a dose-dependent increase.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
CCK-8 assay of HCT116 and SW480 cells treated with APM (Aspartame) for 24, 48, and 72 h.
Purity & Documentation
References
[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727. [Content Brief]
[2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aspartame acesulfame Related Classifications
HY-118347 Related Classifications
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