Aspartame acesulfame
Based on 3 publication(s) in Google Scholar
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).
For research use only. We do not sell to patients.
- CAS No.: 106372-55-8
- Formula: C18H23N3O9S
- Molecular Weight:457.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Aspartame acesulfame
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Biological Activity
Description
In Vitro
Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 106372-55-8
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Molecular Weight 457.45
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Formula C18H23N3O9S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Environ Pollut
Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1. [Abstract]2024 Nov 15:361:124792. PMID: 39182820 -
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Naunyn Schmiedebergs Arch Pharmacol
Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer. [Abstract]2026 Jun 19. PMID: 42319418
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
Venn diagram showing the overlap between CRC-related candidate genes and APM (Aspartame) candidate targets, resulting in 26 APM-CRC common candidate genes.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
Heatmap of the binding energies between APM and the five key target proteins.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
EdU staining showed that, compared with the DMSO control group, the number of EdU-positive cells in HCT116 and SW480 cells was significantly increased after APM (Aspartame, 0.001-0.1 mM) treatment, exhibiting a dose-dependent increase.
Aspartame acesulfame purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2026 Jun 19. [Abstract]
CCK-8 assay of HCT116 and SW480 cells treated with APM (Aspartame) for 24, 48, and 72 h.
Purity & Documentation
References
[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727. [Content Brief]
[2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aspartame acesulfame Related Classifications
HY-118347 Related Classifications
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