URAT1 inhibitor 4
URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258).
For research use only. We do not sell to patients.
- CAS No.: 2700292-02-8
- Formula: C27H20BrN3O4S3
- Molecular Weight:626.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 7.56 ± 0.52 μM (URAT1), 55.96 ± 10.38 μM (GLUT9)[1]
URAT1 inhibitor 4 (compound 10) inhibits URAT1 and GLUT9 with IC50s of 7.56 ± 0.52 μM and 55.96 ± 10.38 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
URAT1 inhibitor 4 (1000 mg/kg; i.g.; single dosage) exhibits higher survival rate than Lesinurad in mice acute toxicity assessment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (acute hyperuricemia model)[1]
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Dosage:2 mg/kg
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Administration:p.o.; single dosage
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Result:Decreased serum uric acid with an decrease ratio of 73.29%.
Chemical Information
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CAS No. 2700292-02-8
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Molecular Weight 626.56
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Formula C27H20BrN3O4S3
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SMILES
O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
URAT1 inhibitor 4 Related Classifications
HY-152033 Related Classifications
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