2. Membrane Transporter/Ion Channel
  3. URAT1 GLUT
  4. URAT1 inhibitor 4

URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258).

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URAT1 inhibitor 4 Chemical Structure

URAT1 inhibitor 4 Chemical Structure

CAS No. : 2700292-02-8

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URAT1 inhibitor 4 Related Antibodies

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Description

URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258)[1].

IC50 & Target

IC50: 7.56 ± 0.52 μM (URAT1), 55.96 ± 10.38 μM (GLUT9)[1]
In Vitro

URAT1 inhibitor 4 (compound 10) inhibits URAT1 and GLUT9 with IC50s of 7.56 ± 0.52 μM and 55.96 ± 10.38 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

URAT1 inhibitor 4 Related Antibodies
In Vivo

URAT1 inhibitor 4 (2 mg/kg; p.o.; single dosage) decreases serum uric acid level in acute hyperuricemia model mice[1].
URAT1 inhibitor 4 (1000 mg/kg; i.g.; single dosage) exhibits higher survival rate than Lesinurad in mice acute toxicity assessment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (acute hyperuricemia model)[1]
Dosage: 2 mg/kg
Administration: p.o.; single dosage
Result: Decreased serum uric acid with an decrease ratio of 73.29%.
Animal Model: Kunming mice[1]
Dosage: 1000 mg/kg
Administration: i.g.; single dosage
Result: Survival rate was 100% after 7 days, while Lesinurad were 40% (male) and 20% (female).
Molecular Weight

626.56

Formula

C27H20BrN3O4S3
CAS No.
SMILES

O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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URAT1 inhibitor 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URAT1 inhibitor 42700292-02-8URAT1GLUTUrate transporter 1SLC22A12Glucose transporterLesinuradserum uric acidacute?hyperuricemiaInhibitorinhibitorinhibit

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