2700292-02-8
2700292-02-8
Chemical Structure
URAT1 inhibitor 4
- CAS No.: 2700292-02-8
- Formula:C27H20BrN3O4S3
- Molecular Weight:626.56
IUPAC Name: N-((4-bromophenyl)sulfonyl)-2-((3-(4-cyclopropylnaphthalen-1-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide
InChIKey: DOVYBMLGVFODNY-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3
Biological Activity: URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258)[1].
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URAT1 inhibitor 4 | URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258). | |||||||||||||||||||||
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References
Keywords
