2. Anti-infection Apoptosis
  3. Bacterial Fungal Antibiotic Apoptosis
  4. Triclosan

Triclosan 

Cat. No.: HY-B1119 Purity: 99.88%
COA Handling Instructions

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

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Triclosan Chemical Structure

Triclosan Chemical Structure

CAS No. : 3380-34-5

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10 mM * 1 mL in DMSO
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Based on 5 publication(s) in Google Scholar

Other Forms of Triclosan:

Triclosan Related Antibodies

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Description

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].

In Vitro

Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2[2].
Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins[2].
Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triclosan Related Antibodies

Cell Viability Assay[2]

Cell Line: Neural stem wells
Concentration: 1, 10, 20, 30, 50 and 100 μM
Incubation Time: 24 h
Result: Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.

Western Blot Analysis[2]

Cell Line: Neural stem wells
Concentration: 50 μM
Incubation Time: 1, 3 h
Result: Did not affect the expressions of MAPK signaling proteins per se.
Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.
In Vivo

Triclosan (5, 50, 500 mg/kg; oral gavage, five days a week for a total of four weeks) causes an increase in the production of anti‐Der f IgE, IL‐4, and IL‐13[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type BALB/cJ mice[3]
Dosage: 5, 50, 500 mg/kg
Administration: Oral gavage, five days a week for a total of four weeks
Result: Caused an increase in the production of anti- dermatophagoides farinae (Der f) IgE, IL‐4, and IL‐13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen‐exposed wild type mice.
Clinical Trial
Molecular Weight

289.54

Appearance

Solid

Formula

C12H7Cl3O2
CAS No.
SMILES

OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (345.38 mM)

H2O : 1 mg/mL (3.45 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4538 mL 17.2688 mL 34.5375 mL
5 mM 0.6908 mL 3.4538 mL 6.9075 mL
10 mM 0.3454 mL 1.7269 mL 3.4538 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (248 KB) HNMR (111 KB) RP-HPLC (189 KB)

Handling Instructions (2659 KB)
References
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Triclosan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Triclosan3380-34-5BacterialFungalAntibioticApoptosisAntibacterialfatty acid synthesisenoyl-acyl carrier protein reductaseFabIFabIG93Vneural stem cellscolitiscolorectal tumorigenesisInhibitorinhibitorinhibit

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