Triclosan-13C6
Based on 1 Customer Validation
Triclosan-13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
For research use only. We do not sell to patients.
- CAS No.: 2726926-25-4
- Formula: C613C6H7Cl3O2
- Molecular Weight:295.50
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2726926-25-4
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Unlabeled Cas 3380-34-5
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Appearance Solid
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Molecular Weight 295.50
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Formula C613C6H7Cl3O2
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Color White to light brown
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SMILES
OC1=CC(Cl)=CC=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13CH]2)Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
Methanol : 100 mg/mL (338.41 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (338.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136. [Content Brief]
[3]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4. [Content Brief]
[4]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol / DMSO | 1 mM | 3.3841 mL | 16.9205 mL | 33.8409 mL | 84.6024 mL |
| 5 mM | 0.6768 mL | 3.3841 mL | 6.7682 mL | 16.9205 mL | |
| 10 mM | 0.3384 mL | 1.6920 mL | 3.3841 mL | 8.4602 mL | |
| 15 mM | 0.2256 mL | 1.1280 mL | 2.2561 mL | 5.6402 mL | |
| 20 mM | 0.1692 mL | 0.8460 mL | 1.6920 mL | 4.2301 mL | |
| 25 mM | 0.1354 mL | 0.6768 mL | 1.3536 mL | 3.3841 mL | |
| 30 mM | 0.1128 mL | 0.5640 mL | 1.1280 mL | 2.8201 mL | |
| 40 mM | 0.0846 mL | 0.4230 mL | 0.8460 mL | 2.1151 mL | |
| 50 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6920 mL | |
| 60 mM | 0.0564 mL | 0.2820 mL | 0.5640 mL | 1.4100 mL | |
| 80 mM | 0.0423 mL | 0.2115 mL | 0.4230 mL | 1.0575 mL | |
| 100 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8460 mL |
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