1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Lavoltidine

Lavoltidine (Synonyms: Loxtidine; AH-234844)

Cat. No.: HY-121450
Handling Instructions

Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia.

For research use only. We do not sell to patients.

Lavoltidine Chemical Structure

Lavoltidine Chemical Structure

CAS No. : 76956-02-0

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Description

Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia[1].

IC50 & Target[1]

H2 Receptor

 

In Vivo

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis-infected INS-GAS mice[1].
Lavoltidine treatment for 6 months inhibits gastric tumors in H felis-infected INS-GAS mice[1].

Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis[1]
Dosage: 0.5 g/L
Administration: Orally (drinking water); changed weekly; for 3 months
Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia.
Molecular Weight

359.47

Formula

C₁₉H₂₉N₅O₂

CAS No.

76956-02-0

SMILES

OCC1=NN(C(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=N1)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LavoltidineLoxtidineAH-234844AH234844AH 234844Histamine ReceptororallyirreversiblegastricacidsecretionhypergastrinemiatumorsHfelisInhibitorinhibitorinhibit

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