1. Anti-infection
    Metabolic Enzyme/Protease
  2. Parasite
    Endogenous Metabolite
  3. L-Canaline

L-Canaline 

Cat. No.: HY-129476
Handling Instructions

L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects.

For research use only. We do not sell to patients.

L-Canaline Chemical Structure

L-Canaline Chemical Structure

CAS No. : 496-93-5

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Description

L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].

IC50 & Target

IC50: 297 nM (Plasmodium falciparum)[3];
Ornithine aminotransferase[1]

In Vitro

L-Canaline treatment inhibits the proliferation of PBMCs after stimulation by phorbol 12-myristate-13-acetate (PMA) or via the mixed lymphocyte reaction. The greatest effect is seen with PMA-stimulated cells, where L-canaline has an IC50 of 0.26 mM. L-Canaline is slightly less toxic to PBMCs stimulated via the mixed lymphocyte reaction (IC50 of 0.54 mM)[1]. L-canaline inhibits L-lysine flux competitively (Ki of 4.6 mM) in astrocytes and astrocytoma cells[2].

In Vivo

L-Canaline decreases the aspartic acid content of tissues of the medulla oblongata of male Wistar rats, but it does not affect the evoked release of this nonprotein amino acid into these tissues[2].
Intraseptal injection of 100 μg of L-canaline into male Sprague-Dawley rats causes a 90% decrease in the omithine aminotransferase activity of the septum tissues evaluated from animals killed 1 h later[2].

Molecular Weight

134.13

Formula

C₄H₁₀N₂O₃

CAS No.

496-93-5

SMILES

N[[email protected]@H](CCON)C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

L-CanalineParasiteEndogenous MetaboliteL-Canavaninearginaseanticancerantiproliferativecytotoxicpolyamine nonproteinaminoacidoximesInhibitorinhibitorinhibit

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L-Canaline
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