1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite Mitochondrial Metabolism
  3. Malonyl CoA

Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Malonyl CoA lithium) usually boasts enhanced water solubility and stability.

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Malonyl CoA Chemical Structure

Malonyl CoA Chemical Structure

CAS No. : 524-14-1

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Description

Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Malonyl CoA (20 μM, 6 min) decreases CPT1 activity by 75% in MCF-7 cells[2].
Malonyl CoA (0-3 μM) inhibits CPT1 activity in liver mitochondria from fed virgin female rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

853.58

Formula

C24H38N7O19P3S

CAS No.
SMILES

O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Malonyl CoA
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HY-115899
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