524-14-1
524-14-1
Chemical Structure
Malonyl CoA
Synonym(s): Malonyl coenzyme A
- CAS No.: 524-14-1
- Formula:C24H38N7O19P3S
- Molecular Weight:853.58
IUPAC Name: (ethyne-1,2-diylbis(4,1-phenylene))diboronic acid
InChIKey: LTYOQGRJFJAKNA-DVVLENMVSA-N
SMILES: O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2
Biological Activity: Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].
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Malonyl CoA | Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1. | |||||||||||||||||||||
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References
- [1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. [Content Brief]
- [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. [Content Brief]
