1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)
    Acetyl-CoA Carboxylase
  3. S-2E

S-2E 

Cat. No.: HY-139134
Handling Instructions

S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.

For research use only. We do not sell to patients.

S-2E Chemical Structure

S-2E Chemical Structure

CAS No. : 155730-92-0

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Description

S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research[1][2].

In Vivo

In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibits the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at Ki=18.11 μM and Ki=69.2 μM, respectively[1].
S-2E (3-30 mg/kg) given orally suppresses the secretion rate of very-low-density lipoprotein (VLDL)-cholesterol and triglyceride in Triton WR-1339-injected rats. Furthermore, S-2E lowers the blood total cholesterol and triglyceride levels simultaneously in Zucker fatty rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.44

Formula

C22H25NO4

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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S-2E
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HY-139134
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