Tau-aggregation and neuroinflammation-IN-1
Based on 1 Customer Validation
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 2175953-98-5
- Formula: C25H20N2O7
- Molecular Weight:460.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AcPHF6, tau-aggregation, NO[1]
Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM[1].
Tau-aggregation and neuroinflammation-IN-1 (2.5, 5 and 10 μM; 24 hours) retains the anti-inflammatory activity of sodium usnate and inhibits NO release rate by 41% in LPS-stimulated BV2 cells at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y, LO2 and BV-2 cells[1]
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Concentration:0, 10, 20, 30 and 40 μM
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Incubation Time:24 hours
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Result:Reduced the survival of SH-SY5Y cells at 30 μM, and exerted no significant hepatotoxicity in LO2 cells even at high concentrations (up to 40 μM), also exerted no effect on BV2 cell viability at 20 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD rats (250-270 g; OA was microinjected into the right dorsal hippocampus)[1]
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Dosage:5 and 10 mg/kg
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Administration:IP; for 7 days, and after OA-injection continued IP for 7 days
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Result:Led to a substantial improvement of the conventional reference spatial memory and cognitive abilities of rats.
Chemical Information
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CAS No. 2175953-98-5
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Appearance Solid
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Molecular Weight 460.44
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Formula C25H20N2O7
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Color Light yellow to yellow
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SMILES
O=C(O)C1=CC=C(N2N=C(C)C3=C2C=C(OC4=C(C(C)=O)C(O)=C(C)C(O)=C45)[C@]5(C)C3=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (271.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1718 mL | 10.8592 mL | 21.7184 mL | 54.2959 mL |
| 5 mM | 0.4344 mL | 2.1718 mL | 4.3437 mL | 10.8592 mL | |
| 10 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 5.4296 mL | |
| 15 mM | 0.1448 mL | 0.7239 mL | 1.4479 mL | 3.6197 mL | |
| 20 mM | 0.1086 mL | 0.5430 mL | 1.0859 mL | 2.7148 mL | |
| 25 mM | 0.0869 mL | 0.4344 mL | 0.8687 mL | 2.1718 mL | |
| 30 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8099 mL | |
| 40 mM | 0.0543 mL | 0.2715 mL | 0.5430 mL | 1.3574 mL | |
| 50 mM | 0.0434 mL | 0.2172 mL | 0.4344 mL | 1.0859 mL | |
| 60 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9049 mL | |
| 80 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6787 mL | |
| 100 mM | 0.0217 mL | 0.1086 mL | 0.2172 mL | 0.5430 mL |
Tau-aggregation and neuroinflammation-IN-1 Related Classifications
HY-146005 Related Classifications
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