Tau-aggregation and neuroinflammation-IN-1

Name: Tau-aggregation and neuroinflammation-IN-1
Brand: MedChemExpress
SKU: HY-146005
Rating: 4.5 (1 reviews)

Cat. No.: HY-146005 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats.

For research use only. We do not sell to patients.

Tau-aggregation and neuroinflammation-IN-1 Chemical Structure

CAS No. : 2175953-98-5

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

AcPHF6, tau-aggregation, NO^[1]

In Vitro

Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM^[1].
Tau-aggregation and neuroinflammation-IN-1 (2.5, 5 and 10 μM; 24 hours) retains the anti-inflammatory activity of sodium usnate and inhibits NO release rate by 41% in LPS-stimulated BV2 cells at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	SH-SY5Y, LO2 and BV-2 cells^[1]
Concentration:	0, 10, 20, 30 and 40 μM
Incubation Time:	24 hours
Result:	Reduced the survival of SH-SY5Y cells at 30 μM, and exerted no significant hepatotoxicity in LO2 cells even at high concentrations (up to 40 μM), also exerted no effect on BV2 cell viability at 20 μM.

In Vivo

Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SD rats (250-270 g; OA was microinjected into the right dorsal hippocampus)^[1]
Dosage:	5 and 10 mg/kg
Administration:	IP; for 7 days, and after OA-injection continued IP for 7 days
Result:	Led to a substantial improvement of the conventional reference spatial memory and cognitive abilities of rats.

Molecular Weight

460.44

Formula

C₂₅H₂₀N₂O₇

CAS No.

2175953-98-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(N2N=C(C)C3=C2C=C(OC4=C(C(C)=O)C(O)=C(C)C(O)=C45)[C@]5(C)C3=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (271.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1718 mL	10.8592 mL	21.7184 mL
5 mM	0.4344 mL	2.1718 mL	4.3437 mL
10 mM	0.2172 mL	1.0859 mL	2.1718 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (258 KB) HNMR (283 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Shi CJ, Peng W, Zhao JH, et al. Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors. Eur J Med Chem. 2020;187:111961. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1718 mL	10.8592 mL	21.7184 mL	54.2959 mL
	5 mM	0.4344 mL	2.1718 mL	4.3437 mL	10.8592 mL
	10 mM	0.2172 mL	1.0859 mL	2.1718 mL	5.4296 mL
	15 mM	0.1448 mL	0.7239 mL	1.4479 mL	3.6197 mL
	20 mM	0.1086 mL	0.5430 mL	1.0859 mL	2.7148 mL
	25 mM	0.0869 mL	0.4344 mL	0.8687 mL	2.1718 mL
	30 mM	0.0724 mL	0.3620 mL	0.7239 mL	1.8099 mL
	40 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3574 mL
	50 mM	0.0434 mL	0.2172 mL	0.4344 mL	1.0859 mL
	60 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9049 mL
	80 mM	0.0271 mL	0.1357 mL	0.2715 mL	0.6787 mL
	100 mM	0.0217 mL	0.1086 mL	0.2172 mL	0.5430 mL