1. Membrane Transporter/Ion Channel
    Anti-infection
  2. Proton Pump
    Bacterial
  3. Vonoprazan hydrochloride

Vonoprazan hydrochloride (Synonyms: TAK-438 hydrochloride)

Cat. No.: HY-100007A
Handling Instructions

Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori.

For research use only. We do not sell to patients.

Vonoprazan hydrochloride Chemical Structure

Vonoprazan hydrochloride Chemical Structure

CAS No. : 1957202-44-6

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Description

Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori[1][2][3].

IC50 & Target

IC50: 19 nM (porcine gastric H+,K+-ATPase, at pH 6.5)[2]

In Vitro

Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H+, K+-ATPase activity in a concentration-dependent manner[2].
Vonoprazan does not inhibit Na+,K+-ATPase activity, even at concentrations 500 times higher than their IC50 values against gastric H+,K+-ATPase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 7- or 8-week-old Sprague-Dawley rat[2]
Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Oral administration
Result: Inhibited basal gastric acid secretion in a dose-dependent manner.
Molecular Weight

381.85

Formula

C17H17ClFN3O2S

CAS No.
SMILES

O=S(C1=CC=CN=C1)(N2C=C(CNC)C=C2C3=C(F)C=CC=C3)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Vonoprazan hydrochloride
Cat. No.:
HY-100007A
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