1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Vonoprazan Fumarate

Vonoprazan Fumarate (Synonyms: TAK-438)

Cat. No.: HY-15295 Purity: 99.97%
Handling Instructions

Vonoprazan Fumarate (TAK-438) is an orally active potassium-competitive acid blocker which inhibits H+, K+-ATPase activity with an IC50 of 19 nM.

For research use only. We do not sell to patients.

Vonoprazan Fumarate Chemical Structure

Vonoprazan Fumarate Chemical Structure

CAS No. : 1260141-27-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 297 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 970 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Vonoprazan Fumarate:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Vonoprazan Fumarate (TAK-438) is an orally active potassium-competitive acid blocker which inhibits H+, K+-ATPase activity with an IC50 of 19 nM.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1670 mL 10.8352 mL 21.6704 mL
5 mM 0.4334 mL 2.1670 mL 4.3341 mL
10 mM 0.2167 mL 1.0835 mL 2.1670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

461.46

Formula

C₂₁H₂₀FN₃O₆S

CAS No.

1260141-27-2

SMILES

FC(C=CC=C1)=C1C2=CC(CNC)=CN2S(=O)(C3=CC=CN=C3)=O.OC(/C=C/C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.97%

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Vonoprazan Fumarate
Cat. No.:
HY-15295
Quantity:

Vonoprazan Fumarate

Cat. No.: HY-15295