1. Membrane Transporter/Ion Channel
    Anti-infection
  2. Proton Pump
    Bacterial
  3. Vonoprazan

Vonoprazan  (Synonyms: TAK-438 free base)

Cat. No.: HY-100007 Purity: 99.61%
COA Handling Instructions

Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori.

For research use only. We do not sell to patients.

Vonoprazan Chemical Structure

Vonoprazan Chemical Structure

CAS No. : 881681-00-1

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Vonoprazan:

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  • Biological Activity

  • Purity & Documentation

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Description

Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori[1][2][3].

IC50 & Target

IC50: 19 nM (porcine gastric H+,K+-ATPase, at pH 6.5)[2]

In Vitro

Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H+, K+-ATPase activity in a concentration-dependent manner[2].
Vonoprazan does not inhibit Na+,K+-ATPase activity, even at concentrations 500 times higher than their IC50 values against gastric H+,K+-ATPase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 7- or 8-week-old Sprague-Dawley rat[2]
Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Oral administration
Result: Inhibited basal gastric acid secretion in a dose-dependent manner.
Clinical Trial
Molecular Weight

345.39

Formula

C17H16FN3O2S

CAS No.
SMILES

O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8953 mL 14.4764 mL 28.9528 mL
5 mM 0.5791 mL 2.8953 mL 5.7906 mL
10 mM 0.2895 mL 1.4476 mL 2.8953 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.61%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vonoprazan
Cat. No.:
HY-100007
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