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  4. L-Arginine butanoate

L-Arginine butanoate  (Synonyms: (S)-(+)-Arginine butanoate)

Cat. No.: HY-N0455D Purity: 98.0%
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L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations.

For research use only. We do not sell to patients.

CAS No. : 80407-72-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of L-Arginine butanoate:

L-Arginine butanoate Related Antibodies

Top Publications Citing Use of Products

    L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e10500.  [Abstract]

    Intracellular ROS and NO generation were measured under different L-Arg (25-200 mg/mL) concentrations following iRGD NPs@si-SOX9/CL+L (24 h) treatment using DCFH-DA and DAF-FM DA probes

    L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333.  [Abstract]

    Images and tumor volume in subcutaneous tumors established with AQP5+ or AQP5− MFC cells in C57BL/6J mice treated with daily oral gavage of different concentrations of L-Arginine (1-2 g/kg; p.o. daily for 27 d) or PBS.

    L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333.  [Abstract]

    Proportion of NK cells in subcutaneous tumors detected by flow cytometry (AQP5+); AQP5+ + L-Arginine (1 g/kg daily oral gavage); AQP5+ + L-Arginine (2 g/kg daily oral gavage); AQP5-).

    L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333.  [Abstract]

    NK cells co-cultured with AQP5+ AGS cells, AQP5- AGS cells, or AQP5+ AGS cells supplemented with 40 nM L-Arginine for 48 h and co-cultured with AGS cells. Images detected by live cell workstation; NK cells were labeled green by CFSE, and AGS cells were labeled red.

    L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Nutrients. 2023 Oct 18;15(20):4427.

    A ketogenic diet exacerbated L-Arginine (4 g/kg; hourly i.p. for 2 times )-induced acute pancreatitis. H&E staining and TEM sections of pancreatic tissue.

    • Biological Activity

    • Purity & Documentation

    • Customer Review

    Description

    L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations[1].

    In Vivo

    L-Arginine has been widely accepted as a method to induce experimental acute pancreatitis[4][5].
    Dose reference for L-Arginine induction[4][5]:
    (1) Model animal: Male Wistar albino rats
    Acute pancreatitis: single i.p. injection of 500 mg L-Arginine/100 g body weight
    (2) Model animal: Male ICR mice
    Acute pancreatitis: i.p. with 2.25 g/kg (L-Arginine) hourly for 2 hours
    Dissolution method of L-Arginine[5]:
    L-arginine solution was prepared by dissolving L-arginine powder in 0.9% normal saline and adjusting the pH to 7 with 5 N HCl.
    Induction of Experimental Acute Pancreatitis[4][5]
    Background
    L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS) to produce NO, which can be metabolized into nitric oxide (NO), polyamines or L-proline, stimulating inflammatory responses. L-Arginine can also selectively destroy pancreatic acinar cells, leading to acute necrotizing pancreatitis.
    Specific Modeling Methods
    Rat[4]: Wistar albino rats • Male • 150 g
    Administration: 250 mg, 500 mg, 750 mg (L-Arginine) every 100 g body weight • ip • single dose • starved for 15 hours
    Mice[5]: ICT mouse • Male • 4-week-old • 25-30 g
    Administration: 450 mg/100 g (L-Arginine) • ip • twice dosages • sacrificed at 72 hours
    Note
    (1) When the dose exceeds 500 mg/100 g body weight, most rats will die within a few hours after injection; When the dose is less than 250 mg, the induced symptoms of pancreatic disease will be mild[4].
    (2) Dissolution method in Reference: L-Arginine solution was prepared by dissolving L-Arginine powder in 0.9% normal saline and adjusting pH to 7 with 5N hydrochloric acid[5].
    Modeling Indicators
    Phenotypic changes: weight loss, lower activity, softer hair.
    Tissue morphology: pancreatic edema, damage, atrophy, granulation tissue contraction and chalky spots (location of fat necrosis).
    Cellular changes: basophils decrease and vesicles, cell pyknosis, nuclear fragmentation. Pancreatic albino cells disappear and die, and pancreatic tissue is replaced by monocytes and fibroblasts.
    Molecular changes: serum amylase levels increase, and fat necrosis is obvious.
    Correlated Product(s): Curcumin (HY-N0005)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    291.67

    Formula

    C6H14N4O2.4/3C4H8O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N=C(N)NCCC[C@H](N)C(O)=O.OC(CCC)=O.[4/3]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (342.85 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4285 mL 17.1427 mL 34.2853 mL
    5 mM 0.6857 mL 3.4285 mL 6.8571 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.4285 mL 17.1427 mL 34.2853 mL 85.7133 mL
    5 mM 0.6857 mL 3.4285 mL 6.8571 mL 17.1427 mL
    10 mM 0.3429 mL 1.7143 mL 3.4285 mL 8.5713 mL
    15 mM 0.2286 mL 1.1428 mL 2.2857 mL 5.7142 mL
    20 mM 0.1714 mL 0.8571 mL 1.7143 mL 4.2857 mL
    25 mM 0.1371 mL 0.6857 mL 1.3714 mL 3.4285 mL
    30 mM 0.1143 mL 0.5714 mL 1.1428 mL 2.8571 mL
    40 mM 0.0857 mL 0.4286 mL 0.8571 mL 2.1428 mL
    50 mM 0.0686 mL 0.3429 mL 0.6857 mL 1.7143 mL
    60 mM 0.0571 mL 0.2857 mL 0.5714 mL 1.4286 mL
    80 mM 0.0429 mL 0.2143 mL 0.4286 mL 1.0714 mL
    100 mM 0.0343 mL 0.1714 mL 0.3429 mL 0.8571 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Arginine butanoate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Arginine butanoate80407-72-3(S)-(+)-Arginine butanoateAmino Acid Derivativesnutrientsshort-chain fatty acidfood additiveInhibitorinhibitorinhibit

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