L-Arginine butanoate
Based on 25 publication(s) in Google Scholar
L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 80407-72-3
- Formula: C6H14N4O2.4/3C4H8O2
- Molecular Weight:291.67
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Arginine butanoate
More- Signal Transduct Target Ther. 2025 May 28;10(1):167. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Nat Nanotechnol. 2025 Aug 11. [Abstract]
- Autophagy. 2025 Dec 23:1-25. [Abstract]
- Nat Protoc. 2021 Jan;16(1):431-457. [Abstract]
- Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
- Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
- Int J Nanomedicine. 2024 Nov 21:19:12369-12387. [Abstract]
- J Agric Food Chem. 2026 Feb 11;74(5):4582-4598. [Abstract]
- Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116055. [Abstract]
- Inflammation. 2026 Jan 28;49(1):70. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- iScience. 2026 Jun 23;29(7):116159. [Abstract]
- FASEB J. 2025 Sep 30;39(18):e71057. [Abstract]
- Genes Immun. 2025 Apr;26(2):124-136. [Abstract]
- J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
- J Biomed Mater Res A. 2025 Dec;113(12):e70006. [Abstract]
- Viruses. 2021 Jun 26;13(7):1236. [Abstract]
- Dig Dis Sci. 2023 Feb;68(2):478-486. [Abstract]
- Pancreas. 2020 Jan;49(1):111-119. [Abstract]
- SSRN. 2025 Dec 17.
- Patent. US20230090691A1.
- Trop J Pharm Res. 2022 Jun 4.
- Patent. US20200352840A1.
Customer Validation & Images
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
Biological Activity
Dose reference for L-Arginine induction[4][5]:
(1) Model animal: Male Wistar albino rats
Acute pancreatitis: single i.p. injection of 500 mg L-Arginine/100 g body weight
(2) Model animal: Male ICR mice
Acute pancreatitis: i.p. with 2.25 g/kg (L-Arginine) hourly for 2 hours
Dissolution method of L-Arginine[5]:
L-arginine solution was prepared by dissolving L-arginine powder in 0.9% normal saline and adjusting the pH to 7 with 5 N HCl.
Administration: 250 mg, 500 mg, 750 mg (L-Arginine) every 100 g body weight • ip • single dose • starved for 15 hours
Administration: 450 mg/100 g (L-Arginine) • ip • twice dosages • sacrificed at 72 hours
(2) Dissolution method in Reference: L-Arginine solution was prepared by dissolving L-Arginine powder in 0.9% normal saline and adjusting pH to 7 with 5N hydrochloric acid[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 80407-72-3
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Appearance Solid
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Molecular Weight 291.67
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Formula C6H14N4O2.4/3C4H8O2
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Color White to off-white
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SMILES
N=C(N)NCCC[C@H](N)C(O)=O.OC(CCC)=O.[4/3]
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Synonyms
(S)-(+)-Arginine butanoate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (25)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [Abstract]2025 May 28;10(1):167. PMID: 40425583 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Nat Nanotechnol
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]2025 Aug 11. PMID: 40789923 -
Autophagy
ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease. [Abstract]2025 Dec 23:1-25. PMID: 41376268 -
Nat Protoc
2021 Jan;16(1):431-457. PMID: 33349703 -
Adv Sci (Weinh)
Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]2025 Nov 21:e10500. PMID: 41270217
L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
Intracellular ROS and NO generation were measured under different L-Arg (25-200 mg/mL) concentrations following iRGD NPs@si-SOX9/CL+L (24 h) treatment using DCFH-DA and DAF-FM DA probes
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Cell Rep Med
Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity. [Abstract]2025 Sep 16;6(9):102333. PMID: 40961922
L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Images and tumor volume in subcutaneous tumors established with AQP5+ or AQP5− MFC cells in C57BL/6J mice treated with daily oral gavage of different concentrations of L-Arginine (1-2 g/kg; p.o. daily for 27 d) or PBS.
L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Proportion of NK cells in subcutaneous tumors detected by flow cytometry (AQP5+); AQP5+ + L-Arginine (1 g/kg daily oral gavage); AQP5+ + L-Arginine (2 g/kg daily oral gavage); AQP5-).
L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
NK cells co-cultured with AQP5+ AGS cells, AQP5- AGS cells, or AQP5+ AGS cells supplemented with 40 nM L-Arginine for 48 h and co-cultured with AGS cells. Images detected by live cell workstation; NK cells were labeled green by CFSE, and AGS cells were labeled red.
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Int J Nanomedicine
A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases. [Abstract]2024 Nov 21:19:12369-12387. PMID: 39606561 -
J Agric Food Chem
Protocatechuic Acid, a Gut-Derived Dietary Metabolite, Attenuates Endothelial Dysfunction via GPER-Mediated NO Signaling. [Abstract]2026 Feb 11;74(5):4582-4598. PMID: 41605862 -
Nutrients
Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate. [Abstract]2023 Oct 18;15(20):4427. PMID: 37892502
L-Arginine butanoate purchased from MedChemExpress. Usage Cited in: Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
A ketogenic diet exacerbated L-Arginine (4 g/kg; hourly i.p. for 2 times )-induced acute pancreatitis. H&E staining and TEM sections of pancreatic tissue.
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Int Immunopharmacol
Targeting periodontal inflammatory microenvironment to ameliorate periodontitis: A nitrogen ions implantation technique. [Abstract]2026 Feb 1:170:116055. PMID: 41448003 -
Inflammation
Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways. [Abstract]2026 Jan 28;49(1):70. PMID: 41606267 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
iScience
2026 Jun 23;29(7):116159. PMID: 42389588 -
FASEB J
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging. [Abstract]2025 Sep 30;39(18):e71057. PMID: 40955599 -
Genes Immun
Annexin A1 regulates inflammatory-immune response and reduces pancreatic and extra- pancreatic injury during severe acute pancreatitis. [Abstract]2025 Apr;26(2):124-136. PMID: 40025269 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878 -
J Biomed Mater Res A
Hyaluronic Acid-Chitosan Nanoparticles Encapsulating Gal-9 Alleviate Severe Acute Pancreatitis by Promoting M2 Macrophage Polarization. [Abstract]2025 Dec;113(12):e70006. PMID: 41307175 -
Viruses
Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1. [Abstract]2021 Jun 26;13(7):1236. PMID: 34206713 -
Dig Dis Sci
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin. [Abstract]2023 Feb;68(2):478-486. PMID: 35781653 -
Pancreas
Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis. [Abstract]2020 Jan;49(1):111-119. PMID: 31856086 -
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Solvent & Solubility
H2O : 100 mg/mL (342.85 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (252 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 3.4285 mL | 17.1427 mL | 34.2853 mL | 85.7133 mL |
| 5 mM | 0.6857 mL | 3.4285 mL | 6.8571 mL | 17.1427 mL | |
| 10 mM | 0.3429 mL | 1.7143 mL | 3.4285 mL | 8.5713 mL | |
| 15 mM | 0.2286 mL | 1.1428 mL | 2.2857 mL | 5.7142 mL | |
| 20 mM | 0.1714 mL | 0.8571 mL | 1.7143 mL | 4.2857 mL | |
| 25 mM | 0.1371 mL | 0.6857 mL | 1.3714 mL | 3.4285 mL | |
| 30 mM | 0.1143 mL | 0.5714 mL | 1.1428 mL | 2.8571 mL | |
| 40 mM | 0.0857 mL | 0.4286 mL | 0.8571 mL | 2.1428 mL | |
| 50 mM | 0.0686 mL | 0.3429 mL | 0.6857 mL | 1.7143 mL | |
| 60 mM | 0.0571 mL | 0.2857 mL | 0.5714 mL | 1.4286 mL | |
| 80 mM | 0.0429 mL | 0.2143 mL | 0.4286 mL | 1.0714 mL | |
| 100 mM | 0.0343 mL | 0.1714 mL | 0.3429 mL | 0.8571 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Arginine butanoate Related Classifications
HY-N0455D Related Classifications
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