L-Arginine (L-glutamate)
Based on 27 publication(s) in Google Scholar
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 4320-30-3
- Formula: C11H23N5O6
- Molecular Weight:321.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) L-Arginine (L-glutamate)
More- Signal Transduct Target Ther. 2025 May 28;10(1):167. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Nat Nanotechnol. 2025 Aug 11. [Abstract]
- Autophagy. 2025 Dec 23:1-25. [Abstract]
- Nat Protoc. 2021 Jan;16(1):431-457. [Abstract]
- Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
- Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
- Int J Nanomedicine. 2024 Nov 21:19:12369-12387. [Abstract]
- J Agric Food Chem. 2026 Feb 11;74(5):4582-4598. [Abstract]
- Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116055. [Abstract]
- Inflammation. 2026 Jan 28;49(1):70. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Brain Res Bull. 2026 Oct 1:244:112037.
- iScience. 2026 Jun 23;29(7):116159. [Abstract]
- FASEB J. 2025 Sep 30;39(18):e71057. [Abstract]
- Genes Immun. 2025 Apr;26(2):124-136. [Abstract]
- J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
- J Biomed Mater Res A. 2025 Dec;113(12):e70006. [Abstract]
- Viruses. 2021 Jun 26;13(7):1236. [Abstract]
- Mol Biol Rep. 2026 Jun 23;53(1):991.
- Dig Dis Sci. 2023 Feb;68(2):478-486. [Abstract]
- Pancreas. 2020 Jan;49(1):111-119. [Abstract]
- SSRN. 2025 Dec 17.
- Patent. US20230090691A1.
- Trop J Pharm Res. 2022 Jun 4.
- Patent. US20200352840A1.
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4320-30-3
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Appearance Solid
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Molecular Weight 321.33
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Formula C11H23N5O6
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Color White to off-white
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SMILES
N[C@@H](CCC(O)=O)C(O)=O.N[C@@H](CCCNC(N)=N)C(O)=O
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Synonyms
(S)-(+)-Arginine (L-glutamate)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (27)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [Abstract]2025 May 28;10(1):167. PMID: 40425583 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Nat Nanotechnol
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]2025 Aug 11. PMID: 40789923 -
Autophagy
ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease. [Abstract]2025 Dec 23:1-25. PMID: 41376268 -
Nat Protoc
2021 Jan;16(1):431-457. PMID: 33349703 -
Adv Sci (Weinh)
Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]2025 Nov 21:e10500. PMID: 41270217
L-Arginine (L-glutamate) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
Intracellular ROS and NO generation were measured under different L-Arg (25-200 mg/mL) concentrations following iRGD NPs@si-SOX9/CL+L (24 h) treatment using DCFH-DA and DAF-FM DA probes
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Cell Rep Med
Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity. [Abstract]2025 Sep 16;6(9):102333. PMID: 40961922
L-Arginine (L-glutamate) purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Images and tumor volume in subcutaneous tumors established with AQP5+ or AQP5− MFC cells in C57BL/6J mice treated with daily oral gavage of different concentrations of L-Arginine (1-2 g/kg; p.o. daily for 27 d) or PBS.
L-Arginine (L-glutamate) purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Proportion of NK cells in subcutaneous tumors detected by flow cytometry (AQP5+); AQP5+ + L-Arginine (1 g/kg daily oral gavage); AQP5+ + L-Arginine (2 g/kg daily oral gavage); AQP5-).
L-Arginine (L-glutamate) purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
NK cells co-cultured with AQP5+ AGS cells, AQP5- AGS cells, or AQP5+ AGS cells supplemented with 40 nM L-Arginine for 48 h and co-cultured with AGS cells. Images detected by live cell workstation; NK cells were labeled green by CFSE, and AGS cells were labeled red.
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Int J Nanomedicine
A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases. [Abstract]2024 Nov 21:19:12369-12387. PMID: 39606561 -
J Agric Food Chem
Protocatechuic Acid, a Gut-Derived Dietary Metabolite, Attenuates Endothelial Dysfunction via GPER-Mediated NO Signaling. [Abstract]2026 Feb 11;74(5):4582-4598. PMID: 41605862 -
Nutrients
Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate. [Abstract]2023 Oct 18;15(20):4427. PMID: 37892502
L-Arginine (L-glutamate) purchased from MedChemExpress. Usage Cited in: Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
A ketogenic diet exacerbated L-Arginine (4 g/kg; hourly i.p. for 2 times )-induced acute pancreatitis. H&E staining and TEM sections of pancreatic tissue.
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Int Immunopharmacol
Targeting periodontal inflammatory microenvironment to ameliorate periodontitis: A nitrogen ions implantation technique. [Abstract]2026 Feb 1:170:116055. PMID: 41448003 -
Inflammation
Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways. [Abstract]2026 Jan 28;49(1):70. PMID: 41606267 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
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iScience
2026 Jun 23;29(7):116159. PMID: 42389588 -
FASEB J
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging. [Abstract]2025 Sep 30;39(18):e71057. PMID: 40955599 -
Genes Immun
Annexin A1 regulates inflammatory-immune response and reduces pancreatic and extra- pancreatic injury during severe acute pancreatitis. [Abstract]2025 Apr;26(2):124-136. PMID: 40025269 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878 -
J Biomed Mater Res A
Hyaluronic Acid-Chitosan Nanoparticles Encapsulating Gal-9 Alleviate Severe Acute Pancreatitis by Promoting M2 Macrophage Polarization. [Abstract]2025 Dec;113(12):e70006. PMID: 41307175 -
Viruses
Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1. [Abstract]2021 Jun 26;13(7):1236. PMID: 34206713 -
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Dig Dis Sci
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin. [Abstract]2023 Feb;68(2):478-486. PMID: 35781653 -
Pancreas
Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis. [Abstract]2020 Jan;49(1):111-119. PMID: 31856086 -
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Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (311.21 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1121 mL | 15.5603 mL | 31.1207 mL | 77.8016 mL |
| 5 mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | 15.5603 mL | |
| 10 mM | 0.3112 mL | 1.5560 mL | 3.1121 mL | 7.7802 mL | |
| 15 mM | 0.2075 mL | 1.0374 mL | 2.0747 mL | 5.1868 mL | |
| 20 mM | 0.1556 mL | 0.7780 mL | 1.5560 mL | 3.8901 mL | |
| 25 mM | 0.1245 mL | 0.6224 mL | 1.2448 mL | 3.1121 mL | |
| 30 mM | 0.1037 mL | 0.5187 mL | 1.0374 mL | 2.5934 mL | |
| 40 mM | 0.0778 mL | 0.3890 mL | 0.7780 mL | 1.9450 mL | |
| 50 mM | 0.0622 mL | 0.3112 mL | 0.6224 mL | 1.5560 mL | |
| 60 mM | 0.0519 mL | 0.2593 mL | 0.5187 mL | 1.2967 mL | |
| 80 mM | 0.0389 mL | 0.1945 mL | 0.3890 mL | 0.9725 mL | |
| 100 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.7780 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.