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  3. L-Leucine

L-Leucine 

Cat. No.: HY-N0486 Purity: >98.0%
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L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

For research use only. We do not sell to patients.

L-Leucine Chemical Structure

L-Leucine Chemical Structure

CAS No. : 61-90-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

IC50 & Target[1]

mTORC1

 

In Vitro

L-Leucine (10 mM) treatment impairs endocrine progenitor cell development[1].
In E13.5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased. When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; P<0.01). Finally, L-Leucine also caused a dose-dependent repressive effect on the mRNA levels of the three genes, namely Ngn3, its target Insm1, and insulin[1].
Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

131.17

Formula

C₆H₁₃NO₂

CAS No.

61-90-5

SMILES

N[[email protected]@H](CC(C)C)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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L-Leucine
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L-Leucine

Cat. No.: HY-N0486