L-Leucine-2-¹³C,¹⁵N

Name: L-Leucine-2- 13 C, 15 N
Brand: MedChemExpress
SKU: HY-N0486S6
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0486S6 Pureza: 98.0%: Ficha de datos
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L-Leucine-2-¹³C,¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

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L-Leucine-2-<sup>13</sup>C,<sup>15</sup>N

L-Leucine-2-¹³C,¹⁵N Estructura química

No. CAS : 285977-88-0

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-2-¹³C,¹⁵N:

L-Leucine In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas mTOR:

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mTOR mTORC1 mTORC2

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Ver todas las isoformas

Human Endogenous Metabolite Microbial Metabolite

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

L-Leucine-2-¹³C,¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway^[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

133.16

Fòrmula

C₅¹³CH₁₃¹⁵NO₂

No. CAS

285977-88-0

Unlabeled CAS

61-90-5

Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[13C@H]([15NH2])C(O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

H₂O : 25 mg/mL (187.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5098 mL	37.5488 mL	75.0976 mL
5 mM	1.5020 mL	7.5098 mL	15.0195 mL
10 mM	0.7510 mL	3.7549 mL	7.5098 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.0%

Select Batch:

Ficha de datos (271 KB) SDS (252 KB)

COA (248 KB) HNMR (243 KB) LCMS (90 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.5098 mL	37.5488 mL	75.0976 mL	187.7441 mL
	5 mM	1.5020 mL	7.5098 mL	15.0195 mL	37.5488 mL
	10 mM	0.7510 mL	3.7549 mL	7.5098 mL	18.7744 mL
	15 mM	0.5007 mL	2.5033 mL	5.0065 mL	12.5163 mL
	20 mM	0.3755 mL	1.8774 mL	3.7549 mL	9.3872 mL
	25 mM	0.3004 mL	1.5020 mL	3.0039 mL	7.5098 mL
	30 mM	0.2503 mL	1.2516 mL	2.5033 mL	6.2581 mL
	40 mM	0.1877 mL	0.9387 mL	1.8774 mL	4.6936 mL
	50 mM	0.1502 mL	0.7510 mL	1.5020 mL	3.7549 mL
	60 mM	0.1252 mL	0.6258 mL	1.2516 mL	3.1291 mL
	80 mM	0.0939 mL	0.4694 mL	0.9387 mL	2.3468 mL
	100 mM	0.0751 mL	0.3755 mL	0.7510 mL	1.8774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.