L-Leucine-2-¹³C,¹⁵N

Name: L-Leucine-2- 13 C, 15 N
Brand: MedChemExpress
SKU: HY-N0486S6
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0486S6 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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L-Leucine-2-¹³C,¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

For research use only. We do not sell to patients.

L-Leucine-2-<sup>13</sup>C,<sup>15</sup>N

L-Leucine-2-¹³C,¹⁵N Chemical Structure

CAS No. : 285977-88-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-2-¹³C,¹⁵N:

L-Leucine In-stock
L-Leucine (Standard) In-stock

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•Related Small Molecules:

•Related Proteins:

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Leucine-2-¹³C,¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway^[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

133.16

Formula

C₅¹³CH₁₃¹⁵NO₂

CAS No.

285977-88-0

Unlabeled CAS

61-90-5

Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[13C@H]([15NH2])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (187.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5098 mL	37.5488 mL	75.0976 mL
5 mM	1.5020 mL	7.5098 mL	15.0195 mL
10 mM	0.7510 mL	3.7549 mL	7.5098 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) HNMR (243 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.5098 mL	37.5488 mL	75.0976 mL	187.7441 mL
	5 mM	1.5020 mL	7.5098 mL	15.0195 mL	37.5488 mL
	10 mM	0.7510 mL	3.7549 mL	7.5098 mL	18.7744 mL
	15 mM	0.5007 mL	2.5033 mL	5.0065 mL	12.5163 mL
	20 mM	0.3755 mL	1.8774 mL	3.7549 mL	9.3872 mL
	25 mM	0.3004 mL	1.5020 mL	3.0039 mL	7.5098 mL
	30 mM	0.2503 mL	1.2516 mL	2.5033 mL	6.2581 mL
	40 mM	0.1877 mL	0.9387 mL	1.8774 mL	4.6936 mL
	50 mM	0.1502 mL	0.7510 mL	1.5020 mL	3.7549 mL
	60 mM	0.1252 mL	0.6258 mL	1.2516 mL	3.1291 mL
	80 mM	0.0939 mL	0.4694 mL	0.9387 mL	2.3468 mL
	100 mM	0.0751 mL	0.3755 mL	0.7510 mL	1.8774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.