1. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  2. mTOR Endogenous Metabolite
  3. L-Leucine-13C

L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

For research use only. We do not sell to patients.

L-Leucine-<sup>13</sup>C Chemical Structure

L-Leucine-13C Chemical Structure

CAS No. : 74292-94-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 82 In-stock
Solution
10 mM * 1 mL in DMSO USD 82 In-stock
Solid
25 mg USD 75 In-stock
50 mg USD 120 In-stock
100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

132.17

Formula

C513CH13NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[C@H](N)[13C](O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (37.83 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5660 mL 37.8301 mL 75.6601 mL
5 mM 1.5132 mL 7.5660 mL 15.1320 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.5660 mL 37.8301 mL 75.6601 mL 189.1503 mL
5 mM 1.5132 mL 7.5660 mL 15.1320 mL 37.8301 mL
10 mM 0.7566 mL 3.7830 mL 7.5660 mL 18.9150 mL
15 mM 0.5044 mL 2.5220 mL 5.0440 mL 12.6100 mL
20 mM 0.3783 mL 1.8915 mL 3.7830 mL 9.4575 mL
25 mM 0.3026 mL 1.5132 mL 3.0264 mL 7.5660 mL
30 mM 0.2522 mL 1.2610 mL 2.5220 mL 6.3050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Leucine-13C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Leucine-13C
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