L-Arginine arginine

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L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.

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CAS No. : 37466-21-0

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Other In-stock Forms of L-Arginine arginine:

L-Arginine L-Arginine hydrochloride L-Arginine (L-glutamate) L-Arginine butanoate

Other Forms of L-Arginine arginine:

L-Arginine In-stock
L-Arginine hydrochloride In-stock
L-Arginine (L-glutamate) In-stock
L-Arginine butanoate In-stock
L-Arginine-¹³C₆,d₁₄ hydrochloride Get quote

23 Publications Citing Use of MCE L-Arginine arginine

Cell Imaging/Staining

In Vivo Efficacy Study

Flow Cytometry

: L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]; Intracellular ROS and NO generation were measured under different L-Arg (25-200 mg/mL) concentrations following iRGD NPs@si-SOX9/CL+L (24 h) treatment using DCFH-DA and DAF-FM DA probes

: L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]; Images and tumor volume in subcutaneous tumors established with AQP5⁺ or AQP5⁻ MFC cells in C57BL/6J mice treated with daily oral gavage of different concentrations of L-Arginine (1-2 g/kg; p.o. daily for 27 d) or PBS.

: L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]; Proportion of NK cells in subcutaneous tumors detected by flow cytometry (AQP5⁺); AQP5⁺ + L-Arginine (1 g/kg daily oral gavage); AQP5⁺ + L-Arginine (2 g/kg daily oral gavage); AQP5^-).

: L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]; NK cells co-cultured with AQP5⁺ AGS cells, AQP5^- AGS cells, or AQP5⁺ AGS cells supplemented with 40 nM L-Arginine for 48 h and co-cultured with AGS cells. Images detected by live cell workstation; NK cells were labeled green by CFSE, and AGS cells were labeled red.

: L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Nutrients. 2023 Oct 18;15(20):4427.; A ketogenic diet exacerbated L-Arginine (4 g/kg; hourly i.p. for 2 times )-induced acute pancreatitis. H&E staining and TEM sections of pancreatic tissue.

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Description	L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis^[1]^[2]^[3]^[4]^[5].
Molecular Weight	354.36
Formula	C₁₅H₂₂N₄O₆
CAS No.	37466-21-0
SMILES	OC(C1=C(C=CC=C1)OC(C)=O)=O.N=C(N)NCCC[C@H](N)C(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [Content Brief] [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [Content Brief] [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. [Content Brief] [4]. Mizunuma T, et al. Effects of injecting excess arginine on rat pancreas. J Nutr. 1984 Mar;114(3):467-71. [Content Brief] [5]. Siriviriyakul P, et al. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice. Heliyon. 2019 Aug 27;5(8):e02222. [Content Brief]