L-Arginine arginine
Based on 25 publication(s) in Google Scholar
L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.
For research use only. We do not sell to patients.
- CAS No.: 37466-21-0
- Formula: C15H22N4O6
- Molecular Weight:354.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) L-Arginine arginine
More- Signal Transduct Target Ther. 2025 May 28;10(1):167. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Nat Nanotechnol. 2025 Aug 11. [Abstract]
- Autophagy. 2025 Dec 23:1-25. [Abstract]
- Nat Protoc. 2021 Jan;16(1):431-457. [Abstract]
- Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
- Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
- Int J Nanomedicine. 2024 Nov 21:19:12369-12387. [Abstract]
- J Agric Food Chem. 2026 Feb 11;74(5):4582-4598. [Abstract]
- Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116055. [Abstract]
- Inflammation. 2026 Jan 28;49(1):70. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- iScience. 2026 Jun 23;29(7):116159. [Abstract]
- FASEB J. 2025 Sep 30;39(18):e71057. [Abstract]
- Genes Immun. 2025 Apr;26(2):124-136. [Abstract]
- J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
- J Biomed Mater Res A. 2025 Dec;113(12):e70006. [Abstract]
- Viruses. 2021 Jun 26;13(7):1236. [Abstract]
- Dig Dis Sci. 2023 Feb;68(2):478-486. [Abstract]
- Pancreas. 2020 Jan;49(1):111-119. [Abstract]
- SSRN. 2025 Dec 17.
- Patent. US20230090691A1.
- Trop J Pharm Res. 2022 Jun 4.
- Patent. US20200352840A1.
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
All Endogenous Metabolite Isoforms
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Biological Activity
Chemical Information
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CAS No. 37466-21-0
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Molecular Weight 354.36
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Formula C15H22N4O6
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SMILES
OC(C1=C(C=CC=C1)OC(C)=O)=O.N=C(N)NCCC[C@H](N)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (25)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [Abstract]2025 May 28;10(1):167. PMID: 40425583 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Nat Nanotechnol
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]2025 Aug 11. PMID: 40789923 -
Autophagy
ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease. [Abstract]2025 Dec 23:1-25. PMID: 41376268 -
Nat Protoc
2021 Jan;16(1):431-457. PMID: 33349703 -
Adv Sci (Weinh)
Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]2025 Nov 21:e10500. PMID: 41270217
L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e10500. [Abstract]
Intracellular ROS and NO generation were measured under different L-Arg (25-200 mg/mL) concentrations following iRGD NPs@si-SOX9/CL+L (24 h) treatment using DCFH-DA and DAF-FM DA probes
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Cell Rep Med
Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity. [Abstract]2025 Sep 16;6(9):102333. PMID: 40961922
L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Images and tumor volume in subcutaneous tumors established with AQP5+ or AQP5− MFC cells in C57BL/6J mice treated with daily oral gavage of different concentrations of L-Arginine (1-2 g/kg; p.o. daily for 27 d) or PBS.
L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
Proportion of NK cells in subcutaneous tumors detected by flow cytometry (AQP5+); AQP5+ + L-Arginine (1 g/kg daily oral gavage); AQP5+ + L-Arginine (2 g/kg daily oral gavage); AQP5-).
L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Sep 16;6(9):102333. [Abstract]
NK cells co-cultured with AQP5+ AGS cells, AQP5- AGS cells, or AQP5+ AGS cells supplemented with 40 nM L-Arginine for 48 h and co-cultured with AGS cells. Images detected by live cell workstation; NK cells were labeled green by CFSE, and AGS cells were labeled red.
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Int J Nanomedicine
A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases. [Abstract]2024 Nov 21:19:12369-12387. PMID: 39606561 -
J Agric Food Chem
Protocatechuic Acid, a Gut-Derived Dietary Metabolite, Attenuates Endothelial Dysfunction via GPER-Mediated NO Signaling. [Abstract]2026 Feb 11;74(5):4582-4598. PMID: 41605862 -
Nutrients
Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate. [Abstract]2023 Oct 18;15(20):4427. PMID: 37892502
L-Arginine arginine purchased from MedChemExpress. Usage Cited in: Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
A ketogenic diet exacerbated L-Arginine (4 g/kg; hourly i.p. for 2 times )-induced acute pancreatitis. H&E staining and TEM sections of pancreatic tissue.
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Int Immunopharmacol
Targeting periodontal inflammatory microenvironment to ameliorate periodontitis: A nitrogen ions implantation technique. [Abstract]2026 Feb 1:170:116055. PMID: 41448003 -
Inflammation
Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways. [Abstract]2026 Jan 28;49(1):70. PMID: 41606267 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
iScience
2026 Jun 23;29(7):116159. PMID: 42389588 -
FASEB J
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging. [Abstract]2025 Sep 30;39(18):e71057. PMID: 40955599 -
Genes Immun
Annexin A1 regulates inflammatory-immune response and reduces pancreatic and extra- pancreatic injury during severe acute pancreatitis. [Abstract]2025 Apr;26(2):124-136. PMID: 40025269 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878 -
J Biomed Mater Res A
Hyaluronic Acid-Chitosan Nanoparticles Encapsulating Gal-9 Alleviate Severe Acute Pancreatitis by Promoting M2 Macrophage Polarization. [Abstract]2025 Dec;113(12):e70006. PMID: 41307175 -
Viruses
Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1. [Abstract]2021 Jun 26;13(7):1236. PMID: 34206713 -
Dig Dis Sci
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin. [Abstract]2023 Feb;68(2):478-486. PMID: 35781653 -
Pancreas
Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis. [Abstract]2020 Jan;49(1):111-119. PMID: 31856086 -
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Purity & Documentation
References
[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [Content Brief]
[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [Content Brief]
[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. [Content Brief]
[4]. Mizunuma T, et al. Effects of injecting excess arginine on rat pancreas. J Nutr. 1984 Mar;114(3):467-71. [Content Brief]
[5]. Siriviriyakul P, et al. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice. Heliyon. 2019 Aug 27;5(8):e02222. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)