2. Metabolic Enzyme/Protease
  3. ATP Citrate Lyase
  4. (-)-Hydroxycitric acid

(-)-Hydroxycitric acid  (Synonyms: Garcinia acid)

Cat. No.: HY-16007 Purity: ≥98.0%
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Handling Instructions Technical Support

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss.

For research use only. We do not sell to patients.

(-)-Hydroxycitric acid Chemical Structure

(-)-Hydroxycitric acid Chemical Structure

CAS No. : 27750-10-3

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Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Hydroxycitric acid:

(-)-Hydroxycitric acid Related Antibodies

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  • Purity & Documentation

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Description

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss[1][2].

In Vitro

(-)-Hydroxycitric acid (0-50 µM) reduces lipid droplets accumulation, and decreases ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level in primary chicken hepatocytes[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Hydroxycitric acid Related Antibodies
In Vivo

(-)-Hydroxycitric acid (1.0 mg/kg embryos, injection) reduces lipid droplets accumulation, triglyceride content, lipogenesis factors mRNA level and increases lipolysis factors mRNA expression in chicken embryos[3].
(-)-Hydroxycitric acid (p.o., once) shows a LD50 of greater than 5000 mg/kg in fasted male and female Albino rats[5].
(-)-Hydroxycitric acid (1000-3000 mg/kg diet for 8 weeks) reduces body weight gain, increases feed conversion ratio, and promotes protein synthesis in rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

208.12

Formula

C6H8O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@](CC(O)=O)(C(O)=O)[C@@H](C(O)=O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7.69 mg/mL (36.95 mM; ultrasonic and adjust pH to 3 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8049 mL 24.0246 mL 48.0492 mL
5 mM 0.9610 mL 4.8049 mL 9.6098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 25 mg/mL (120.12 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8049 mL 24.0246 mL 48.0492 mL 120.1230 mL
5 mM 0.9610 mL 4.8049 mL 9.6098 mL 24.0246 mL
10 mM 0.4805 mL 2.4025 mL 4.8049 mL 12.0123 mL
15 mM 0.3203 mL 1.6016 mL 3.2033 mL 8.0082 mL
20 mM 0.2402 mL 1.2012 mL 2.4025 mL 6.0062 mL
25 mM 0.1922 mL 0.9610 mL 1.9220 mL 4.8049 mL
30 mM 0.1602 mL 0.8008 mL 1.6016 mL 4.0041 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(-)-Hydroxycitric acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Hydroxycitric acid27750-10-3Garcinia acidATP Citrate LyaseACLYFattyacidATPcitratelyaseobesitylipid dropletsInhibitorinhibitorinhibit

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