Ferroportin
Iron-regulated Transporter 1
Ferroportin is a membrane protein belonging to the major facilitator superfamily of transporters. Ferroportin emerges as a critical transporter in terms of iron acquisition and transfer of iron between cell types, as it is the only known transporter that exports elemental iron from cells. Ferroportin is essential to distribute iron between tissues and for iron absorption into the organism. It is inferred that the substrate for ferroportin is Fe(II), based on the observation that iron transport requires an extracellular ferroxidase activity. This ferroxidase is provided by the multicopper oxidases ceruloplasmin (Cp) and/or hephaestin. Several ferroportin mutations lead to the so-called ferroportin disease or type 4 hemochromatosis, characterized by two distinct iron accumulation phenotypes depending on whether the mutation affects the activity of the protein or its degradation pathway.
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Ferroportin Related Products (18)
Related Products (18)
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Antibodies (3)
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VIT-2763
0 ImagesVIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of β-thalassemia.
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Rusfertide
0 ImagesSynonyms: PTG-300Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis.
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Apo-Bovine Transferrin
0 ImagesCat. No.: HY-P3267ACAS No.: 11096-37-0Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe2+ to Fe3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research.
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DMT1 blocker 2
0 ImagesDMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.
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DMT1 blocker 1
0 ImagesDMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia.
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Ferroptosis inducer-16
0 ImagesCat. No.: HY-182052CAS No.: 3063042-21-4Synonyms: anti-NSCLC agent-2Ferroptosis inducer-16 (anti-NSCLC agent-2) is a nitric oxide (NO) donor and a ferroptosis inducer. Ferroptosis inducer-16 inhibits DNA synthesis and colony formation. Ferroptosis inducer-16 disrupts lysosomal integrity by releasing NO, triggers iron overload and oxidative stress, downregulates the SLC7A11-GPX4 axis, depletes GSH, and accumulates lipid peroxides. Ferroptosis inducer-16 inhibits tumor growth in an OVCAR8/ADR xenograft mouse model without obvious toxicity, and can be used in the study of non-small cell lung cancer and drug-resistant ovarian cancer.
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Hepcidin antagonist-1
0 ImagesHepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC50<50 μM. Hepcidin antagonist-1 can be used for researching iron metabolism disorders, such as anemias.
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DS28120313
0 ImagesDS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
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Ferroportin-IN-1
0 ImagesFerroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders.
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KY1070
0 ImagesCat. No.: HY-P991881KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
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LY2928057
0 ImagesCat. No.: HY-P990618Purity: 99.9%
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Fursultiamine (Standard)
0 ImagesFursultiamine (Standard) is the analytical standard of Fursultiamine. This product is intended for research and analytical applications. Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1 deficiency, osteoarthritis (OA) and cancer research.
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Pyrimidinone 8
0 ImagesCat. No.: HY-124703CAS No.: 65004-42-4Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.
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DS42450411
0 ImagesCat. No.: HY-125288CAS No.: 2247168-13-2DS42450411 is an orally active hepcidin production inhibitor with an IC50 of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis.
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Anti-SLC40A1 Antibody
0 ImagesCat. No.: HY-P990510Anti-SLC40A1 Antibody is a human-derived antibody expressed in CHO, targeting SLC40A1. The predicted molecular weight (MW) of Anti-SLC40A1 Antibody is 150 kDa.
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DS28120313 (Standard)
0 ImagesCat. No.: HY-107980RCAS No.: 2146177-09-3DS28120313 (Standard) is the analytical standard of DS28120313 (HY-107980). This product is intended for research and analytical applications. DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
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Schizokinen
0 ImagesCat. No.: HY-119771CAS No.: 35418-52-1Schizokinen is an iron-transport agent. Schizokinen can be obtained from Bacillus megaterium. Schizokinen possesses a higher affinity for iron(III) than Desferrioxamine B. Schizokinen reduces the division lag of bacteria.
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