1. Others
  2. Others
  3. DMT1 blocker 2

DMT1 blocker 2 

Cat. No.: HY-126302 Purity: 99.08%
Handling Instructions

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

For research use only. We do not sell to patients.

DMT1 blocker 2 Chemical Structure

DMT1 blocker 2 Chemical Structure

CAS No. : 1062648-63-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo[1].

IC50 & Target

IC50: 0.83 μM (divalent metal transporter 1)[1]

In Vitro

DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells[1].
DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks[1]
Dosage: 50 mg/kg
Administration: Oral gavage followed 1 h later by an iron challenge
Result: Attenuated the post-challenge serum iron increase.
Molecular Weight

263.29

Formula

C₁₆H₁₃N₃O

CAS No.

1062648-63-8

SMILES

OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (189.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7981 mL 18.9905 mL 37.9809 mL
5 mM 0.7596 mL 3.7981 mL 7.5962 mL
10 mM 0.3798 mL 1.8990 mL 3.7981 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DMT1 blocker 2OthersdirectdivalentmetaltransporterDMT1ironuptakeenterocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DMT1 blocker 2
Cat. No.:
HY-126302
Quantity:
MCE Japan Authorized Agent: