1354790-56-9
Chemical Structure
DMT1 blocker 1
- CAS No.: 1354790-56-9
- Formula:C16H14N4O2
- Molecular Weight:294.31
IUPAC Name: 5-hydroxy-3-methyl-N-phenyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxamide
InChIKey: KKFHSHLFNHRNEL-UHFFFAOYSA-N
SMILES: OC1=C(C(NC2=CC=CC=C2)=O)C(C)=NN1C3=NC=CC=C3
Biological Activity: DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1].
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DMT1 blocker 1 | 99.71% | DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia. | ||||||||||||||||||||
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Keywords
