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DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.

For research use only. We do not sell to patients.

DS28120313 Chemical Structure

DS28120313 Chemical Structure

CAS No. : 2146177-09-3

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1].

IC50 & Target

IC50: 0.093 μM (hepcidin production)[1]
In Vivo

DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

311.34

Formula

C16H17N5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(NN=C1C2CC2)=C1C3=CC(NC(OC)=O)=C(C=NN4)C4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (40.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2119 mL 16.0596 mL 32.1192 mL
5 mM 0.6424 mL 3.2119 mL 6.4238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2119 mL 16.0596 mL 32.1192 mL 80.2981 mL
5 mM 0.6424 mL 3.2119 mL 6.4238 mL 16.0596 mL
10 mM 0.3212 mL 1.6060 mL 3.2119 mL 8.0298 mL
15 mM 0.2141 mL 1.0706 mL 2.1413 mL 5.3532 mL
20 mM 0.1606 mL 0.8030 mL 1.6060 mL 4.0149 mL
25 mM 0.1285 mL 0.6424 mL 1.2848 mL 3.2119 mL
30 mM 0.1071 mL 0.5353 mL 1.0706 mL 2.6766 mL
40 mM 0.0803 mL 0.4015 mL 0.8030 mL 2.0075 mL
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DS28120313 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS281203132146177-09-3DS 28120313DS-28120313OthersInhibitorinhibitorinhibit

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