9031-37-2
Chemical Structure
Biological Activity: Ceruloplasmin is a copper-binding ferroxidase and serum copper carrier. Ceruloplasmin promotes FPN1-mediated iron export by catalyzing ferrous iron oxidation, maintains the protein stability of ferroportin, and assists transferrin and lactoferrin in completing iron binding; it regulates HIF, AMPK, PPARα, and PGC1α, exerting antioxidant effects and inhibiting ferroptosis (Ferroptosis). Ceruloplasmin can be used in research on posthemorrhagic anemia, hemolytic anemia, neurodegenerative diseases, NAFLD, metabolic diseases, hereditary aceruloplasminemia, hepatocellular carcinoma, and ischemia-reperfusion injury[1][2][3][4][5][6][7][8][9][10].
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Ceruloplasmin | Ceruloplasmin is a copper-binding ferroxidase and serum copper carrier. Ceruloplasmin promotes FPN1-mediated iron export by catalyzing ferrous iron oxidation, maintains the protein stability of ferroportin, and assists transferrin and lactoferrin in completing iron binding; it regulates HIF, AMPK, PPARα, and PGC1α, exerting antioxidant effects and inhibiting ferroptosis (Ferroptosis). Ceruloplasmin can be used in research on posthemorrhagic anemia, hemolytic anemia, neurodegenerative diseases, NAFLD, metabolic diseases, hereditary aceruloplasminemia, hepatocellular carcinoma, and ischemia-reperfusion injury. | |||||||||||||||||||||
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References
- [1]. Kostevich VA, et al. Functional link between ferroxidase activity of ceruloplasmin and protective effect of apo-lactoferrin: studying rats kept on a silver chloride diet. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2016 Aug;29(4):691-704.
- [2]. Li ZD, et al. The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice. Cell death & disease. 2022 Nov 28;13(11):1006. [Content Brief]
- [3]. DiSilvestro PD. Effects of ascorbic acid and inflammation on ceruloplasmin activity levels in guinea pigs. Nutrition Research. 1986 Aug 1;6(8):1009-12.
- [4]. Diaz D, et al. MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats. Toxicologic pathology. 2017 Feb;45(2):353-361.
- [5]. Tian S, et al. Chloride Control of the Mechanism of Human Ceruloplasmin Catalysis. Journal of the American Chemical Society. 2019 Jun 27;141(27):10736.
- [6]. Xie L, et al. Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. Cell reports. 2022 Oct 18;41(3).
- [7]. Liu Z, et al. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes, metabolic syndrome and obesity : targets and therapy. 2022;15:695-711.
- [8]. Martin F, et al. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation. Blood. 2005 Jun 15;105(12):4613-9.
- [9]. Shang Y, et al. Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Cellular signalling. 2020 Aug;72:109633.
- [10]. Seyid M, et al. The Effect of Ceruloplasmin Against Ischemia-Reperfusion Injury in Epigastric Island Flap in Rats. J Surg Res. 2021 Nov;267:627-635.
