65004-42-4
65004-42-4
Chemical Structure
Pyrimidinone 8
- CAS No.: 65004-42-4
- Formula:C10H12N4O
- Molecular Weight:204.23
IUPAC Name: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(1H)-one
InChIKey: XIFVEJXUSTTZKD-UHFFFAOYSA-N
SMILES: O=C1N=C(N2N=C(C)C=C2C)NC(C)=C1
Biological Activity: Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1].
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Pyrimidinone 8 | Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM. | |||||||||||||||||||||
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References
Keywords
