2. Membrane Transporter/Ion Channel
  3. Ferroportin
  4. DS42450411

DS42450411 is an orally active hepcidin production inhibitor with an IC50 of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis.

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DS42450411

DS42450411 Chemical Structure

CAS No. : 2247168-13-2

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Description

DS42450411 is an orally active hepcidin production inhibitor with an IC50 of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
0.032 μM
Compound: 34; DS42450411
Inhibition of BMP6-stimulated hepcidin production in human HepG2 cells
Inhibition of BMP6-stimulated hepcidin production in human HepG2 cells
[PMID: 30217414]
Molecular Weight

348.48

Formula

C22H28N4
CAS No.
SMILES

NC1=C2C(C)(C)CC3=CC(C([C@H]4CC[C@H](N)CC4)=C)=CC=C3C2=NC=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS42450411 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS424504112247168-13-2DS 42450411DS-42450411FerroportinIron-regulated Transporter 1Hepcidin inhibitorDYRK1aAnemia of chronic diseaseOral bioavailabilityStructure-activity relationshipInhibitorinhibitorinhibit

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